Evidence map›Paper›PMID 29057271›Full record

ArticleBioMed research international2017

Overexpression of MicroRNA-145 Ameliorates Astrocyte Injury by Targeting Aquaporin 4 in Cerebral Ischemic Stroke.

Lifang Zheng, Wei Cheng, Xijia Wang, Zhigang Yang, Xiangling Zhou, Chunlian Pan

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 66 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Lifang ZhengDepartment of Neurology, The Puren Hospital, Wuhan University of Science and Technology, Wuhan 430081, China.
Wei ChengDepartment of Neurology, The Puren Hospital, Wuhan University of Science and Technology, Wuhan 430081, China.
Xijia WangDepartment of Neurology, The Puren Hospital, Wuhan University of Science and Technology, Wuhan 430081, China.
Zhigang YangDepartment of Neurology, The Puren Hospital, Wuhan University of Science and Technology, Wuhan 430081, China.
Xiangling ZhouDepartment of Neurology, The Puren Hospital, Wuhan University of Science and Technology, Wuhan 430081, China.
Chunlian PanDepartment of Neurology, The Puren Hospital, Wuhan University of Science and Technology, Wuhan 430081, China.ORCID 0000-0001-8315-9719
Wuhan University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral ischemic stroke, which affects the global population, is a major disease with high incidence, mortality, and disability. Accumulating evidence has indicated that abnormal microRNA (miRNA) expression plays essential roles in the pathologies of ischemic stroke. Yet, the underlying regulatory mechanism of miRNAs in cerebral ischemic stroke remains unclear. We investigated the role of miR-145 in cerebral ischemic stroke and its potential mechanism in a model using primary cultured astrocytes. We detected the expression levels of miR-145 and its target gene

Indexed as

AnimalsApoptosisAquaporin 4AstrocytesBrain IschemiaGene Expression RegulationGlucoseHumansMicroRNAsNeuronsOxygenPrimary Cell CultureRatsStrokeAqp4 protein, ratAquaporin 4GlucoseMicroRNAsMIRN145 microRNA, ratOxygen

Identifiers

PMID29057271
PMCPMC5615955
OpenAlexW2754025821

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.