Evidence map›Paper›PMID 29057222›Full record

ArticleFrontiers in chemistry2017

Identification of Trombospondin-1 as a Novel Amelogenin Interactor by Functional Proteomics.

Angela Capolupo, Chiara Cassiano, Agostino Casapullo, Giuseppina Andreotti, Maria V Cubellis, Andrea Riccio, Raffaele Riccio, Maria C Monti

Open access · goldAbstract read
In one paragraph

Article in Frontiers in chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Angela CapolupoDepartment of Pharmacy, University of Salerno, Salerno, Italy.
Chiara CassianoDepartment of Pharmacy, University of Salerno, Salerno, Italy.
Agostino CasapulloDepartment of Pharmacy, University of Salerno, Salerno, Italy.
Giuseppina AndreottiIstituto di Chimica Biomolecolare, Consiglio Nazionale Delle Ricerche (CNR), Napoli, Italy.
Maria V CubellisDepartment of Biology, University of Naples Federico II, Napoli, Italy.
Andrea RiccioDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, Caserta, Italy.
Raffaele RiccioDepartment of Pharmacy, University of Salerno, Salerno, Italy.
Maria C MontiDepartment of Pharmacy, University of Salerno, Salerno, Italy.
University of Salerno · ITIstituto di Chimica Biomolecolare · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amelogenins are a set of low molecular-weight enamel proteins belonging to a group of extracellular matrix (ECM) proteins with a key role in tooth enamel development and in other regeneration processes, such as wound healing and angiogenesis. Since only few data are actually available to unravel amelogenin mechanism of action in chronic skin healing restoration, we moved to the full characterization of the human amelogenin isoform 2 interactome in the secretome and lysate of Human Umbilical Vein Endothelial cells (HUVEC), using a functional proteomic approach. Trombospondin-1 has been identified as a novel and interesting partner of human amelogenin isoform 2 and their direct binding has been validated thought biophysical orthogonal approaches.

Indexed as

amelogeninextracellular matrix proteinsfunctional proteomicsprotein-protein interactionthrombospondin-1wound healing

Identifiers

PMID29057222
PMCPMC5635807
OpenAlexW2761858024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.