Evidence map›Paper›PMID 29057202›Full record

ArticleCurrent transplantation reports2015

Autoimmune Reactivity in Graft Injury: Player or Bystander?

Vrushali V Agashe, William J Burlingham

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current transplantation reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Vrushali V AgasheComparative Biomedical Sciences Graduate Program.
William J BurlinghamDepartment of Surgery-Transplant division, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI 53795, USA.
University of Wisconsin–Madison · US

Funding

Transgenic Mouse CoreP01AI084853 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI WILKES, DAVID S · 2010 to 2014
$7.7M
Natural vs. Pathogenic Th17 responses to col Va1, Ka1tubulin and vimentinR01AI119140 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI SULLIVAN, JEREMY A · 2016 to 2020
$1.9M
Detection of IL35+ Exosomes as a Marker for Peripheral ToleranceR03AI146688 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI FOLEY, DAVID PAUL · 2020 to 2021
$155k
NIAID NIH HHS P01 AI084853NIAID NIH HHS R01 AI119140NIAID NIH HHS R03 AI146688
6 · The paper itself

Abstract

Organ transplantation is the only viable treatment for several end-stage organ failures. However chronic rejection prevents long-term graft survival. Traditionally this rejection was attributed to the development of alloimmunity in transplant patients. However recent evidence suggests that autoimmunity plays a larger role in chronic rejection of certain organ transplants, than alloimmunity. In this review we will focus on the history of autoimmunity in solid-organ transplantation and at look the Collagen Type V, K-α-tubulin, Vimentin, Cardiac myosin and Heat Shock Proteins as classical examples of auto-antigens in organ transplantation. We will also look at some of the recent reports looking at the mechanisms of autoimmunity and try to provide answers to some of the age-old questions in autoimmunity.

Indexed as

AutoimmunityCardiac myosinCollagen Type VHeat shock protein 65K-α-tubulinVimentin

Identifiers

PMID29057202
PMCPMC5650227
OpenAlexW766544893

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.