ArticleCurrent addiction reports2017
Cannabis Withdrawal: A Review of Neurobiological Mechanisms and Sex Differences.
Article in Current addiction reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- A Systematic Review of the Efficacy of Cannabinoid Agonist Replacement Therapy for Cannabis Withdrawal Symptoms.CNS drugs · 2018Pooled it
- Brain imaging of cannabinoid type I (CBAddiction biology · 2021Trial
- Effects of cannabis use on alcohol consumption in a sample of treatment-engaged heavy drinkers in Colorado.Addiction (Abingdon, England) · 2021Trial
- Increased encoding of aversive stimuli by lateral habenula neurons during ΔNature communications · 2026Article
- Consumption patterns and withdrawal symptoms in dual cannabis-tobacco users in Spain: Cross-sectional study.Addictive behaviors reports · 2026Article
- Mental health consequences of contemporary cannabis use in Europe: potency, patterns of use, and health system context.Frontiers in psychiatry · 2026Review
- Cannabis and liver transplant in the era of legalization: Effects of pretransplant cannabis use on postoperative opioid use and transplant outcomes.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2025Article
- Circuit mechanisms governing endocannabinoid modulation of affective behaviour and stress adaptation.Nature reviews. Neuroscience · 2025Review
- The role of sex in the association between cannabis use disorder and resting-state functional connectivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Cannabis and psychopathology: 2024 Snapshot of a meandering journey.Indian journal of psychiatry · 2025Review
- Network topology and cannabis use following two weeks of monitored abstinence: moderation of sex and patterns of use findings.Frontiers in adolescent medicine · 2025Article
- The Developmental Trajectory to Cannabis Use Disorder.The American journal of psychiatry · 2024Article
- Differential disruption of response alternation by precipitated ΔPharmacology, biochemistry, and behavior · 2024Article
- Edible cannabis for chronic low back pain: associations with pain, mood, and intoxication.Frontiers in pharmacology · 2024Article
- Alcohol First, Cannabis Last: Identification of an Especially Risky Use Pattern among Individuals Who Co-Use Alcohol and Cannabis.Substance use & misuse · 2024Article
- Consuming oral cannabidiol prior to a standard alcohol dose has minimal effect on breath alcohol level and subjective effects of alcohol.Psychopharmacology · 2023Article
- Impact of erector spinae plane block on the quality of recovery after lumbar spine decompression surgery: A comparative study between addicts and non-addicts.Indian journal of anaesthesia · 2023Article
- Association between Cannabis Use Disorder and Mental Health Disorders in the Adolescent Population: A Cohort Study.European addiction research · 2023Article
- The role of sex in the association between cannabis use and working memory-related brain activity.Journal of neuroscience research · 2022Article
- Effects of cannabinoid exposure on short-term memory and medial orbitofrontal cortex function and chemistry in adolescent female rhesus macaques.Frontiers in neuroscience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewThis report provides an updated overview of pre-clinical and clinical research on the etiology and biological substrates of the cannabis withdrawal syndrome. RECENT
findingsLong-term cannabis use is associated with downregulation of type-1 cannabinoid receptors (CB SUMMARY: Recent studies have extended knowledge of the biological processes and individual difference variables that influence cannabis withdrawal. However, caveats include small sample sizes in clinical studies, participant samples that are predominantly male, and limited examinations of endocannabinoids, enzymes that degrade endocannabinoids, negative allosteric modulators, and other neurobiological systems that may directly impact cannabis withdrawal symptom expression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.