Evidence map›Paper›PMID 29057172›Full record

ArticleJournal of gerontology & geriatric research2017

Cerebral and Retinal Neurovascular Changes: A Biomarker for Alzheimer's Disease.

Karru Venkata Ravi Teja, Tjm Tos Berendschot, Harry Steinbusch, A B Carroll Webers, R Praveen Murthy, P S Mathuranath

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of gerontology & geriatric research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Karru Venkata Ravi TejaDepartment of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru-560029, India.
Tjm Tos BerendschotUniversity Eye Clinic Maastricht University Medical Center, Universiteitssingel 40, Maastricht, The Netherlands.
Harry SteinbuschDepartment of Translational Neuroscience, Faculty of Health, Medicine & Life Sciences, Maastricht University Medical Center, Universiteitssingel 40, Maastricht, The Netherlands.
A B Carroll WebersUniversity Eye Clinic Maastricht University Medical Center, Universiteitssingel 40, Maastricht, The Netherlands.
R Praveen MurthyPrabha Eye Clinic, Bengaluru, India.
P S MathuranathDepartment of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru-560029, India.

Funding

Kerala-Einstein Study: Healthy lifestyle, vascular disease, and cognitive declineR01AG039330 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI MATHURANATH, PAVAGADA S, VERGHESE, JOE · 2011 to 2023
$5.0M
NIA NIH HHS R01 AG039330
6 · The paper itself

Abstract

objectivesBiomarker quest for Alzheimer's disease (AD) has gone a long way by studying various anatomical, physiological and biochemical parameters for detecting disease onset and predicting prognosis. Almost all the studies converge on the single hypothesis of the amyloid and Tau pathway. Recently, vascular hypothesis has evolved drawing attention towards a complex dynamic anatomical and physiological entity, neuro-vascular (NV) unit. Pathological changes at this level, altering the normal physiology such as auto-regulation and dynamics of blood brain barrier have been hypothesized as a probable basis for AD. This paper attempts to review the existing data on the vascular hypothesis and the current trends in analyzing the NV unit in AD.

designThis review initially focuses on the cerebral NV coupling followed by the retinal neurovascular coupling that mirrors the cerebral pathophysiology. The pathophysiology and the potential tools to diagnose AD at the level of NV unit are analyzed. Further, it examines the drawbacks in existing methods for analyzing the same.

findingsNone of the current studies have emphasized the importance of studying the complex dynamic NV unit as a whole. This review strongly recommends the combination of vascular and neuro-glial parameters using objective methods for estimating the physiological and pathological changes in the NV unit. DISCUSSION AND

conclusionThis review highlights the importance of retina for non-invasive estimation of the same. Also, novel algorithms for retinal image analysis have been proposed. The purpose of this review is to highlight the importance of retinal findings in neurodegenerative disorders and to create awareness among the neuroophthalmologists, of the potential benefits of ophthalmological tools in screening dementia patients.

Indexed as

Alzheimer’s diseaseBiomarkerNeurovascular unitRetina

Identifiers

PMID29057172
PMCPMC5648348

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.