Evidence map›Paper›PMID 29057163›Full record

ArticleTranslational vision science & technology2017

Characterization of Long Working Distance Optical Coherence Tomography for Imaging of Pediatric Retinal Pathology.

Ruobing Qian, Oscar M Carrasco-Zevallos, Shwetha Mangalesh, Neeru Sarin, Lejla Vajzovic, Sina Farsiu, Joseph A Izatt, Cynthia A Toth

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational vision science & technology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01588041 completednot on this map

Intraoperative OCT Guidance of Intraocular Surgery

TypeobservationalSponsorDuke UniversityRan2009 to 2018Enrolled269ConditionsEye Manifestations
NCT02582164 nacompletednot on this map

Long-Working Distance OCT System With Fixation Alignment for Pediatric Imaging

TypeinterventionalSponsorDuke UniversityRan2015 to 2018Enrolled49ConditionsRetinal Diseases, Optic Nerve DiseasesArmsDuke Biomedical Engineering's Long-working distance OCT
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ruobing QianDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Oscar M Carrasco-ZevallosDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Shwetha MangaleshDepartment of Ophthalmology, Duke University Medical Center, Durham, NC, USA.
Neeru SarinDepartment of Ophthalmology, Duke University Medical Center, Durham, NC, USA.
Lejla VajzovicDepartment of Ophthalmology, Duke University Medical Center, Durham, NC, USA.
Sina FarsiuDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Joseph A IzattDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Cynthia A TothDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.

Funding

VISION RESEARCHP30EY005722 · NEI · DUKE UNIVERSITY · PI Vadim Y Arshavsky · 1985 to 2026
$19.3M
Intraoperative OCT Guidance of Intraocular SurgeryR01EY023039 · NEI · DUKE UNIVERSITY · PI IZATT, JOSEPH A, TOTH, CYNTHIA ANN · 2013 to 2016
$3.9M
NEI NIH HHS P30 EY005722NEI NIH HHS R01 EY023039
6 · The paper itself

Abstract

purposeWe determined the feasibility of fovea and optic nerve head imaging with a long working distance (LWD) swept source optical coherence tomography (OCT) prototype in adults, teenagers, and young children.

methodsA prototype swept source OCT system with a LWD (defined as distance from the last optical element of the imaging system to the eye) of 350 mm with custom fixation targets was developed to facilitate imaging of children. Imaging was performed in 49 participants from three age groups: 26 adults, 16 children 13 to 18 years old (teenagers), and seven children under 6 years old (young children) under an approved institutional review board protocol. The imaging goal was to acquire high quality scans of the fovea and optic nerve in each eye in the shortest time possible. OCT B-scans and volumes of the fovea and optic nerve head of each eligible eye were captured and graded based on four categories (lateral and axial centration, contrast, and resolution) and on ability to determine presence or absence of pathology.

resultsLWD-OCT imaging was successful in 88 of 94 eligible eyes, including seven of 10 eyes of young children. Of the successfully acquired OCT images, 83% of B-scan and volumetric images, including 86% from young children, were graded as high-quality scans. Pathology was observed in high-quality OCT images.

conclusionsThe prototype LWD-OCT system achieved high quality retinal imaging of adults, teenagers, and some young children with and without pathology with reasonable alignment time. TRANSLATIONAL RELEVANCE: The LWD-OCT system can facilitate imaging in children.

Indexed as

long working distanceoptical coherence tomographypediatric imagingretinal imaging

Identifiers

PMID29057163
PMCPMC5644711

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.