Evidence map›Paper›PMID 29057148›Full record

ArticleTremor and other hyperkinetic movements (New York, N.Y.)2017

Postural Tremor and Ataxia Progression in Spinocerebellar Ataxias.

Shi-Rui Gan, Jie Wang, Karla P Figueroa, Stefan M Pulst, Darya Tomishon, Danielle Lee, Susan Perlman, George Wilmot, Christopher M Gomez, Jeremy Schmahmann and 10 more

Registry-linked trialOpen access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Tremor and other hyperkinetic movements (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01060371 (Clinical Research Consortium for the Study of Cerebellar Ataxias), which is not on this map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01060371 recruitingnot on this map

Clinical Research Consortium for the Study of Cerebellar Ataxias (CRC-SCA) for the Natural History Study of and Genetic Modifiers in Spinocerebellar Ataxias (SCA)

TypeobservationalSponsorLauren MooreRan2010 to 2030Enrolled1,400ConditionsSpinocerebellar Ataxia Type 1, Spinocerebellar Ataxia Type 2, Spinocerebellar Ataxia Type 3, Spinocerebellar Ataxia Type 6ArmsGenetic Testing, Blood Collection, Magnetic Resonance Imaging (MRI) Scan, Assessments and Questionnaires, Cerebrospinal Fluid Collection
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Movement Disorders in Hereditary Cerebellar Ataxia.Movement disorders clinical practice · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Tremor in Spinocerebellar Ataxia: A Scoping Review.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Systematic clinical approach for diagnosing upper limb tremor.Journal of neurology, neurosurgery, and psychiatry · 2020
    Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 14 institutions in 2 countries.

Shi-Rui GanDepartment of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Jie WangDepartment of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Karla P FigueroaDepartment of Neurology, University of Utah, Salt Lake City, UT, USA.
Stefan M PulstDepartment of Neurology, University of Utah, Salt Lake City, UT, USA.
Darya TomishonDepartment of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Danielle LeeDepartment of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Susan PerlmanDepartment of Neurology, University of California, Los Angeles, CA, USA.
George WilmotDepartment of Neurology, Emory University, Atlanta, GA, USA.
Christopher M GomezDepartment of Neurology, University of Chicago, Chicago, IL, USA.
Jeremy SchmahmannDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Henry PaulsonDepartment of Neurology, University of Michigan, Ann Arbor, MI, USA.
Vikram G ShakkottaiDepartment of Neurology, University of Michigan, Ann Arbor, MI, USA.
Sarah H YingDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Theresa ZesiewiczDepartment of Neurology, University of South Florida, Tampa, FL, USA.
Khalaf BusharaDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Michael D GeschwindDepartment of Neurology, University of California San Francisco, CA, USA.
Guangbin XiaDepartment of Neurology, School of Medicine, University of New Mexico, Albuquerque, NM, USA.
S H SubramonyDepartment of Neurology, School of Medicine, University of New Mexico, Albuquerque, NM, USA.
Tetsuo AshizawaHouston Methodist Research Institute, Houston, TX, USA.
Sheng-Han KuoDepartment of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Columbia University · USUniversity of Michigan–Ann Arbor · USUniversity of New Mexico · USUniversity of Utah · USEmory University · USFirst Affiliated Hospital of Fujian Medical University · CNHarvard University · USHouston Methodist · USJohns Hopkins University · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of Chicago · USUniversity of Minnesota · USUniversity of South Florida · US

Funding

True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
Clinical Research Consortium for Spinocerebellar AtaxiasRC1NS068897 · NINDS · UNIVERSITY OF FLORIDA · PI ASHIZAWA, TETSUO · 2009 to 2010
$1.0M
The role of glucocerebrosidase and chaperone_mediated autophagy in Parkinsons disK08NS083738 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUO, SHENG-HAN · 2013 to 2017
$940k
NIEHS NIH HHS P30 ES009089NINDS NIH HHS K08 NS083738NINDS NIH HHS RC1 NS068897
6 · The paper itself

Abstract

backgroundPostural tremor can sometimes occur in spinocerebellar ataxias (SCAs). However, the prevalence and clinical characteristics of postural tremor in SCAs are poorly understood, and whether SCA patients with postural tremor have different ataxia progression is not known.

methodsWe studied postural tremor in 315 patients with SCA1, 2, 3, and 6 recruited from the Clinical Research Consortium for Spinocerebellar Ataxias (CRC-SCA), which consists of 12 participating centers in the United States, and we evaluated ataxia progression in these patients from January 2010 to August 2012.

resultsAmong 315 SCA patients, postural tremor was most common in SCA2 patients (SCA1, 5.8%; SCA2, 27.5%; SCA3, 12.4%; SCA6, 16.9%; p = 0.007). SCA3 patients with postural tremor had longer CAG repeat expansions than SCA3 patients without postural tremor (73.67 ± 3.12 vs. 70.42 ± 3.96, p = 0.003). Interestingly, SCA1 and SCA6 patients with postural tremor had a slower rate of ataxia progression (SCA1, β = -0.91, p < 0.001; SCA6, β = -1.28, p = 0.025), while SCA2 patients with postural tremor had a faster rate of ataxia progression (β = 1.54, p = 0.034). We also found that the presence of postural tremor in SCA2 patients could be influenced by repeat expansions of DISCUSSION: Postural tremor could be a clinical feature of SCAs, and the presence of postural tremor could be associated with different rates of ataxia progression. Genetic interactions between ataxia genes might influence the brain circuitry and thus affect the clinical presentation of postural tremor.

Indexed as

AdultDisease ProgressionFemaleHumansLogistic ModelsLongitudinal StudiesMaleMiddle AgedSpinocerebellar AtaxiasTremorTrinucleotide Repeat Expansioncerebellumgeneticsneurodegenerationpostural tremorSpinocerebellar ataxias

Identifiers

PMID29057148
PMCPMC5647398
OpenAlexW2765944875

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.