Evidence map›Paper›PMID 29057059›Full record

ArticleACS medicinal chemistry letters2017

Lucky Switcheroo: Dramatic Potency and Selectivity Improvement of Imidazoline Inhibitors of Human Carbonic Anhydrase VII.

Stanislav Kalinin, Stanislav Kopylov, Tiziano Tuccinardi, Alexander Sapegin, Dmitry Dar'in, Andrea Angeli, Claudiu T Supuran, Mikhail Krasavin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Biochemical profiling of anti-HIV prodrug Elsulfavirine (ElpidaJournal of enzyme inhibition and medicinal chemistry · 2021
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Stanislav KalininSaint Petersburg State University, Saint Petersburg 199034, Russian Federation.
Stanislav KopylovSaint Petersburg State University, Saint Petersburg 199034, Russian Federation.
Tiziano TuccinardiDepartment of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
Alexander SapeginSaint Petersburg State University, Saint Petersburg 199034, Russian Federation.
Dmitry Dar'inSaint Petersburg State University, Saint Petersburg 199034, Russian Federation.
Andrea AngeliNeurofarba Department, Universita degli Studi di Firenze, 50121 Florence, Italy.
Claudiu T SupuranNeurofarba Department, Universita degli Studi di Firenze, 50121 Florence, Italy.
Mikhail KrasavinSaint Petersburg State University, Saint Petersburg 199034, Russian Federation.
St Petersburg University · RUUniversity of Florence · ITUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A substantial improvement of potency and selectivity of imidazoline-based inhibitors of hCA VII (a promising target for the treatment of seizures and neuropathic pain) was achieved by simply switching the position of the benzenesulfonamide moiety from N

Indexed as

2-imidazolinescarbonic anhydrase inhibitorsdocking simulationhydrogen bondingisoform selectivitymolecular dynamicsN-arylimidazolinesnonconserved residueprimary sulfonamidePrivileged scaffoldzinc binding group

Identifiers

PMID29057059
PMCPMC5642015
OpenAlexW2754564069

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.