Evidence map›Paper›PMID 29056883›Full record

ArticleMicroscopy today2017

Tunable substrates improve imaging of viruses and cancer proteins.

Carly E Winton, Brian L Gilmore, Justin R Tanner, A Cameron Varano, Zhi Sheng, Deborah F Kelly

Abstract read
In one paragraph

Article in Microscopy today, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Carly E WintonVirginia Tech Carilion Research Institute, Virginia Tech, Roanoke, VA 24016, USA.
Brian L GilmoreVirginia Tech Carilion Research Institute, Virginia Tech, Roanoke, VA 24016, USA.
Justin R TannerVirginia Tech Carilion Research Institute, Virginia Tech, Roanoke, VA 24016, USA.
A Cameron VaranoVirginia Tech Carilion Research Institute, Virginia Tech, Roanoke, VA 24016, USA.
Zhi ShengVirginia Tech Carilion Research Institute, Virginia Tech, Roanoke, VA 24016, USA.
Deborah F KellyVirginia Tech Carilion Research Institute, Virginia Tech, Roanoke, VA 24016, USA.

Funding

Tunable Microchip Sorting of BRCA1 Nuclear AssembliesR01CA193578 · NCI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI KELLY, DEBORAH F · 2015 to 2020
$1.8M
NCI NIH HHS R01 CA193578
6 · The paper itself

Abstract

Recent breakthroughs in cryo-electron microscopy imaging technology provide an unprecedented view of biology at the nanoscale. To complement these technical advances, here we demonstrate the use of tunable substrates to streamline the isolation of biological entities from human cells. We have tested the capacity of tunable microchip devices using a variety of samples including virus assemblies and the breast cancer susceptibility protein (BRCA1) produced in cancer cells. Overall, microchip applications may shed light on ill-defined clinical issues related to molecular disease mechanisms.

Identifiers

PMID29056883
PMCPMC5648339

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.