Evidence map›Paper›PMID 29056735›Full record

ReviewVeterinary sciences2016

Deviant Behavior: Tick-Borne Pathogens and Inflammasome Signaling.

Dana K Shaw, Erin E McClure, Xiaowei Wang, Joao H F Pedra

Abstract readReview
In one paragraph

Review in Veterinary sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Strain-specific immune response patterns toInfection and immunity · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dana K ShawDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. dshaw@som.umaryland.edu.
Erin E McClureDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. erin.mcclure@umaryland.edu.
Xiaowei WangDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. xiwang@som.umaryland.edu.
Joao H F PedraDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. jpedra@som.umaryland.edu.

Funding

Ubiquitylation and Rickettsial Colonization of a Tick VectorR01AI116523 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PEDRA, JOAO · 2016 to 2025
$6.2M
IMMUNITY AND INFECTIONT32AI007540 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI KAPER, JAMES B · 1998 to 2018
$2.2M
Rickettsial Immunity During Tick TransmissionR01AI093653 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PEDRA, JOAO · 2011 to 2015
$1.8M
NIAID NIH HHS R01 AI093653NIAID NIH HHS R01 AI116523NIAID NIH HHS T32 AI007540
6 · The paper itself

Abstract

In the face of an assault, host cells mount an immediate response orchestrated by innate immunity. Two of the best described innate immune signaling networks are the Toll- and the Nod-like receptor pathways. Extensive work has been done characterizing both signaling cascades with several recent advances on the forefront of inflammasome biology. In this review, we will discuss how more commonly-studied pathogens differ from tick-transmitted microbes in the context of Nod-like receptor signaling and inflammasome formation. Because pathogens transmitted by ticks have unique characteristics, we offer the opinion that these microbes can be used to uncover novel principles of Nod-like receptor biology.

Indexed as

Nod-like receptors (NLR)tick-borne diseasestick-borne pathogens

Identifiers

PMID29056735
PMCPMC5606592

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.