ArticleCell metabolism2017
CANTOS Ushers in a New Calculus of Inflammasome Targeting for Vascular Protection-and Maybe More.
Article in Cell metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Osteopontin in Chronic Inflammatory Diseases: Mechanisms, Biomarker Potential, and Therapeutic Strategies.Biology · 2025Review
- Risk of Cancer After Diagnosis of Cardiovascular Disease.JACC. CardioOncology · 2023Article
- Effects of once-weekly semaglutide 2.4 mg on C-reactive protein in adults with overweight or obesity (STEP 1, 2, and 3): Exploratory analyses of three randomised, double-blind, placebo-controlled, phase 3 trials.EClinicalMedicine · 2023 · on this mapArticle
- The Road to Approval: a Perspective on the Role of Icosapent Ethyl in Cardiovascular Risk Reduction.Current diabetes reports · 2020Review
- IL-1β suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury.The Journal of clinical investigation · 2020Article
- Periodontal Inflammation and the Risk of Cardiovascular Disease.Current atherosclerosis reports · 2020Review
- Cohort Study of Repeated Measurements of Serum Urate and Risk of Incident Atrial Fibrillation.Journal of the American Heart Association · 2019Article
- Heart failure prevention with sodium-glucose cotransporter 2 inhibitors.Journal of diabetes · 2019Article
- Anticytokine Agents: Targeting Interleukin Signaling Pathways for the Treatment of AtherothrombosisCirculation research · 2019Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite overwhelming basic science linking inflammation to the pathobiology of atherothrombosis, the specific clinical evidence indicating cardiovascular benefits from anti-inflammatory pharmacotherapy has been lacking. The CANTOS trial (Ridker et al., 2017a) now provides the first largescale proof of concept that inflammasome targeting can reduce cardiovascular events-and, surprisingly, lung cancer.
Indexed as
Identifiers
29056511What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.