Evidence map›Paper›PMID 29056362›Full record

ArticleExperimental neurology2018

Critical appraisal of pathology transmission in the α-synuclein fibril model of Lewy body disorders.

Negin Nouraei, Daniel M Mason, Kristin M Miner, Michael A Carcella, Tarun N Bhatia, Benjamin K Dumm, Dishaben Soni, David A Johnson, Kelvin C Luk, Rehana K Leak

Open access · greenAbstract read
In one paragraph

Article in Experimental neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
  2. Article
  3. HDAC6 Inhibition Reduces Seeded Tau and α-Synuclein Pathologies in Primary Neuron Cultures and Wild-Type Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Lewy Body Dementias: Controversies and Drug Development.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Review
  15. Article
  16. Heat Shock Protein 70 as a Sex-Skewed Regulator of α-Synucleinopathy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
    Article
  17. Article
  18. Article
  19. Neuronal vulnerability in Parkinson disease: Should the focus be on axons and synaptic terminals?Movement disorders : official journal of the Movement Disorder Society · 2019
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Negin NouraeiGraduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, United States.
Daniel M MasonGraduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, United States.
Kristin M MinerGraduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, United States.
Michael A CarcellaGraduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, United States.
Tarun N BhatiaGraduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, United States.
Benjamin K DummGraduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, United States.
Dishaben SoniGraduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, United States.
David A JohnsonGraduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, United States.
Kelvin C LukDepartment of Pathology, University of Pennsylvania, Philadelphia, PA 19147, United States.
Rehana K LeakGraduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, United States. Electronic address: leakr@duq.edu.
Duquesne University · USUniversity of Pennsylvania · US

Funding

Propagation of Lewy pathology in Parkinsons diseaseR01NS088322 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI LUK, KELVIN C · 2015 to 2025
$4.0M
Impact of N-acetyl cysteine ethyl ester on a-synuclein pathology in the olfactory systemR15NS093539 · NINDS · DUQUESNE UNIVERSITY · PI LEAK, REHANA KHAN · 2015 to 2015
$383k
NINDS NIH HHS R01 NS088322NINDS NIH HHS R15 NS093539
6 · The paper itself

Abstract

Lewy body disorders are characterized by the emergence of α-synucleinopathy in many parts of the central and peripheral nervous systems, including in the telencephalon. Dense α-synuclein

Indexed as

alpha-SynucleinNeurofibrilsAnimalsBehavior, AnimalDisease Models, AnimalHippocampusInclusion BodiesLewy Body DiseaseLimbic SystemMemory DisordersMiceMice, Inbred C57BLNeural PathwaysSynaptic TransmissionTelencephalonalpha-SynucleinBiotinylated dextran aminesEntorhinal cortexfibrilsFluoroGoldHippocampusLewy body, Dementia, -synucleinParkinson's diseaseTract-tracing

Identifiers

PMID29056362
PMCPMC5736319
OpenAlexW2765108357

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.