Evidence map›Paper›PMID 29056360›Full record

ArticleExperimental neurology2018

Photobiomodulation therapy promotes neurogenesis by improving post-stroke local microenvironment and stimulating neuroprogenitor cells.

Luodan Yang, Donovan Tucker, Yan Dong, Chongyun Wu, Yujiao Lu, Yong Li, Juan Zhang, Timon Cheng-Yi Liu, Quanguang Zhang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 2 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 2 syntheses or guidelines pooled it, 160 citations in OpenAlex.

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26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Luodan YangLaboratory of Laser Sports Medicine, College of Physical Education and Sports Science, South China Normal University, Guangzhou, China; Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Donovan TuckerDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Yan DongDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Chongyun WuLaboratory of Laser Sports Medicine, College of Physical Education and Sports Science, South China Normal University, Guangzhou, China.
Yujiao LuDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Yong LiDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Juan ZhangDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Timon Cheng-Yi LiuLaboratory of Laser Sports Medicine, College of Physical Education and Sports Science, South China Normal University, Guangzhou, China.
Quanguang ZhangLaboratory of Laser Sports Medicine, College of Physical Education and Sports Science, South China Normal University, Guangzhou, China; Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA. Electronic address: qzhang@augusta.edu.
Augusta University · USSouth China Normal University · CN

Funding

Low-level Laser Therapy in Global Cerebral IschemiaR01NS086929 · NINDS · AUGUSTA UNIVERSITY · PI ZHANG, QUANGUANG · 2014 to 2018
$1.7M
NINDS NIH HHS R01 NS086929
6 · The paper itself

Abstract

Recent work has indicated that photobiomodulation (PBM) may beneficially alter the pathological status of several neurological disorders, although the mechanism currently remains unclear. The current study was designed to investigate the beneficial effect of PBM on behavioral deficits and neurogenesis in a photothrombotic (PT) model of ischemic stroke in rats. From day 1 to day 7 after the establishment of PT model, 2-minute daily PBM (CW, 808nm, 350mW/cm

Indexed as

Neural Stem CellsNeurogenesisAnimalsBehavior, AnimalBrain IschemiaCell DifferentiationCell ProliferationCellular MicroenvironmentCerebral InfarctionCytokinesDoublecortin ProteinElectron Transport Complex IVLow-Level Light TherapyMaleMicrogliaMitochondriaCytokinesDcx protein, ratDoublecortin ProteinElectron Transport Complex IVInflammationIschemic strokeMitochondrial functionNeurogenesisPhotobiomodulation

Identifiers

PMID29056360
PMCPMC5723531
OpenAlexW2765463414

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.