ArticleCell2017
The Human Knockout Gene CLYBL Connects Itaconate to Vitamin B
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Article in Cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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84citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
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Who cites it
84 citing papers in PubMed, 148 citations in OpenAlex.
- Itaconate metabolism in regulated cell death.Molecular and cellular biochemistry · 2026Review
- Itaconate and its derivatives in human health and diseases.Signal transduction and targeted therapy · 2026Review
- Offense and defense: itaconate mediates bidirectional immune regulation of host-bacteria interaction.Journal of biomedical science · 2026Review
- Targeted silencing of CLYBL with platelet-mimetic siRNA nanoparticles drives itaconate-mediated macrophage reprogramming and protects against sepsis-triggered lung cell death.Cell death discovery · 2026Article
- Humanized extracellular vesicles for efficient RNA delivery.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Discovery of metabolites produced by reactions between central carbon metabolites and cysteine that mark inflammatory macrophages.bioRxiv : the preprint server for biology · 2026Article
- A genetically encoded bifunctional enzyme mitigates redox imbalance and lipotoxicity.Nature metabolism · 2026Article
- Human Genome Safe Harbor Sites: A Comprehensive Review of Criteria, Discovery, Features, and Applications.Cells · 2026Review
- Itaconate modulates myeloid inflammation in myocardial infarction via metabolic and structural reprogramming.Genes & genomics · 2026Article
- Cobamide metabolism, regulation, and adaptation inJournal of bacteriology · 2025Review
- Humanized Extracellular Vesicles for Efficient RNA Delivery.bioRxiv : the preprint server for biology · 2025Article
- A carbon trail to follow: unveiling itaconate's metabolism in vivo.Immunometabolism (Cobham, Surrey) · 2025Article
- In vivo itaconate tracing reveals degradation pathway and turnover kinetics.Nature metabolism · 2025Article
- Pathophysiology of the Neutropenia of GSDIb and G6PC3 Deficiency: Origin, Metabolism and Elimination of 1,5-Anhydroglucitol.Journal of inherited metabolic disease · 2025Review
- JIP4 deficiency causes a lysosomal storage disease arising from impaired cystine efflux.bioRxiv : the preprint server for biology · 2025Article
- CLYBL averts vitamin BNature chemical biology · 2025Article
- Recycling for a cleaner metabolism.Nature chemical biology · 2025Article
- Alveolar and Bone Marrow-derived Macrophages Differ in Metabolism and Glutamine Utilization.American journal of respiratory cell and molecular biology · 2025Article
- Acetylation suppresses breast cancer progression by sustaining CLYBL stability.Journal of translational medicine · 2025Article
- Review
24 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 3 institutions in 2 countries.
Hongying ShenHoward Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute, Cambridge, MA 02141, USA.
Gregory C CampanelloDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Daniel FlickerHoward Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute, Cambridge, MA 02141, USA.
Zenon GrabarekHoward Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Broad Institute, Cambridge, MA 02141, USA.
Junchi HuDrug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031, China.
Cheng LuoDrug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031, China.
Ruma BanerjeeDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Vamsi K MoothaHoward Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute, Cambridge, MA 02141, USA. Electronic address: vamsi@hms.harvard.edu.
Broad Institute · USChinese Academy of Sciences · CNUniversity of Michigan · US
Funding
Chemical Biology of Mitochondria and DiabetesR24DK080261 · NIDDK · DANA-FARBER CANCER INST · PI SPIEGELMAN, BRUCE M. · 2007 to 2016
$13.9MREACTION MECHANISMS OF MAMMALIAN B12-DEPENDENT ENZYMESR01DK045776 · NIDDK · UNIVERSITY OF NEBRASKA LINCOLN · PI RUMA V BANERJEE · 1998 to 2026
$9.7MMitochondrial Parts, Pathways, and PathogenesisR35GM122455 · NIGMS · BROAD INSTITUTE, INC. · PI MOOTHA, VAMSI KRISHNA · 2017 to 2021
$4.0MAn integrated approach to the study of mitochondrial vitamin B12 pathway and type II fatty acid synthesisK99GM124296 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI SHEN, HONGYING · 2017 to 2018
$180kStructural Enzymology of Mitochondrial B12 Trafficking ProteinsF32GM113405 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CAMPANELLO, GREGORY · 2015 to 2016
$112kFunctional characterization of a mitochondrial orphan enzymeF32GM114905 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI SHEN, HONGYING · 2015 to 2016
$109kRole of the mitochondrial calcium uniporter in brown fat physiologyF31DK107187 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI FLICKER, DANIEL ROBERT · 2015 to 2017
$93kNIDDK NIH HHS F31 DK107187NIDDK NIH HHS R24 DK080261NIGMS NIH HHS F32 GM113405NIGMS NIH HHS F32 GM114905NIGMS NIH HHS K99 GM124296NIGMS NIH HHS R35 GM122455
Abstract
CLYBL encodes a ubiquitously expressed mitochondrial enzyme, conserved across all vertebrates, whose cellular activity and pathway assignment are unknown. Its homozygous loss is tolerated in seemingly healthy individuals, with reduced circulating B
Indexed as
Carbon-Carbon LyasesGene Knockout TechniquesHumansMetabolic Networks and PathwaysMitochondriaModels, MolecularSuccinatesVitamin B 12Carbon-Carbon LyasesCLYBL protein, humanitaconic acidSuccinatesVitamin B 12C5 metabolismcitramalyl-CoA lyaseCLYBLhuman geneticsitaconatemetabolismmitochondriasystems biologyvitamin B(12)
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.