Evidence map›Paper›PMID 29056299›Full record

ArticleNeuron2017

Development and Refinement of Functional Properties of Adult-Born Neurons.

Jenelle L Wallace, Martin Wienisch, Venkatesh N Murthy

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Amplification of Olfactory Transduction Currents Implements Sparse Stimulus Encoding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Development of the mammalian main olfactory bulb.Development (Cambridge, England) · 2022
    Review
  15. αFrontiers in cellular neuroscience · 2022
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Jenelle L WallaceMolecules, Cells, and Organisms training program, Harvard University, Cambridge, MA 02138, USA; Center for Brain Science, Harvard University, Cambridge, MA 02138, USA; Department of Molecular & Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
Martin WienischCenter for Brain Science, Harvard University, Cambridge, MA 02138, USA; Department of Molecular & Cellular Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address: wienisch@mit.edu.
Venkatesh N MurthyCenter for Brain Science, Harvard University, Cambridge, MA 02138, USA; Department of Molecular & Cellular Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address: vnmurthy@fas.harvard.edu.

Funding

Functional integration of adult-born neurons into the mammalian brainR01DC013329 · NIDCD · HARVARD UNIVERSITY · PI MURTHY, VENKATESH N · 2013 to 2017
$1.8M
Development and refinement of functional properties of adult-born olfactory bulb neuronsF31DC016482 · NIDCD · HARVARD UNIVERSITY · PI WALLACE, JENELLE LIANE · 2017 to 2018
$65k
NIDCD NIH HHS F31 DC016482NIDCD NIH HHS R01 DC013329
6 · The paper itself

Abstract

New neurons appear only in a few regions of the adult mammalian brain and become integrated into existing circuits. Little is known about the functional development of individual neurons in vivo. We examined the functional life history of adult-born granule cells (abGCs) in the olfactory bulb using multiphoton imaging in awake and anesthetized mice. We found that abGCs can become responsive to odorants soon after they arrive in the olfactory bulb. Tracking identified abGCs over weeks revealed that the robust and broadly tuned responses of most newly arrived abGCs gradually become more selective over a period of ∼3 weeks, but a small fraction achieves broader tuning with maturation. Enriching the olfactory environment of mice prolonged the period over which abGCs were strongly and broadly responsive to odorants. Our data offer direct support for rapid integration of adult-born neurons into existing circuits, followed by experience-dependent refinement of their functional connectivity.

Indexed as

AnimalsMaleMiceMicroscopy, Fluorescence, MultiphotonNeuronsOdorantsOlfactory BulbOlfactory Perceptionadult-born neuronadult neurogenesisGCaMPgranule cellolfactionolfactoryplasticitytwo-photon imaging

Identifiers

PMID29056299
PMCPMC5789450

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.