ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2017
End-stage renal disease after pediatric heart transplantation: A 25-year national cohort study.
Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 28 citations in OpenAlex.
- Pediatric heart-kidney transplantation.JHLT open · 2025Article
- Cardiorenal syndrome: evolving concepts and pediatric knowledge gaps.Pediatric nephrology (Berlin, Germany) · 2025Review
- Acute Kidney Injury Requiring Dialysis After Pediatric Heart Transplant.Pediatric transplantation · 2024Article
- Subsequent kidney transplant after pediatric heart transplant: Prevalence and risk factors.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024Article
- Breaking Under Pressure: Cardiorenal Syndrome and Elevated Central Venous Pressures in Children With Heart Disease.JACC. Advances · 2024Article
- Adult Renal Transplantation in a Patient 28 Years after Heart Transplantation as a Neonate for Hypoplastic Left Heart Syndrome.Case reports in transplantation · 2022Article
- Increased Incidence of Chronic Kidney Injury in African Americans Following Cardiac Transplantation.Journal of racial and ethnic health disparities · 2021Article
- Exploring the developmental tasks of emerging adults after paediatric heart transplantation: a cross-sectional case control study.BMJ open · 2018Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundEnd-stage renal disease (ESRD), defined as the need for chronic dialysis and/or kidney transplantation (KTx), is a known complication after heart transplant (HTx). However, factors associated with ESRD are not well elucidated. The objectives of this study were to determine the prevalence, risk factors, and outcomes associated with ESRD after pediatric HTx.
methodsScientific Registry of Transplant Recipients data were linked, using direct identifiers, to the United States Renal Data System to identify patients (aged ≤ 18 years) who underwent primary HTx between 1989 and 2013. Risk factors for ESRD and death were analyzed using Cox regression analysis.
resultsCombining the above 2 databases identified ~25% additional HTx patients who developed ESRD that were not captured by either database alone. During a median follow-up of 11.8 years, ESRD developed in 276 of 6,901 patients (4%). The actuarial risk of developing ESRD after HTx was 3% at 10 years and 16% at 20 years. Age at HTx > 1 year, African-American race, year of HTx before 2000, hypertension, diabetes mellitus, re-HTx, acute dialysis, graft failure, and hospitalized infection were significant risk factors for ESRD development. Those who remained on chronic dialysis had higher risk of death than those who received KTx (hazard ratio, 31.4; 95% confidence interval, 20.8-48.4; p < 0.0001).
conclusionsESRD after pediatric HTx is more prevalent in HTx survivors than documented by a transplant database alone. A number of factors develop at or after HTx that increase the risk for developing ESRD. Use of KTx in post-HTx ESRD is associated with improved survival.
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