Evidence map›Paper›PMID 29055358›Full record

ReviewOphthalmology2017

Meibomian Gland Disease: The Role of Gland Dysfunction in Dry Eye Disease.

Priyanka Chhadva, Raquel Goldhardt, Anat Galor

3 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 206 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
206citing papers in PubMed, 5 pooled it
15.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05694026 nacompletednot on this mapstarted 2023, after this paper: background citation

Management of Dry Eye With Intense Pulsed Light in Combination With Diquafosol

TypeinterventionalSponsorHe Eye HospitalRan2023 to 2023Enrolled360ConditionsDry EyeArmsIntense pulsed light, Diquafosol tetrasodium
NCT05720754 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Safety and Efficacy of Heated Artificial Tears Under Practical Conditions

TypeinterventionalSponsorHe Eye HospitalRan2023 to 2023Enrolled45ConditionsDry EyeArmsDiquafosol tetrasodium, Heated eye mask
NCT06392438 phase3unknown statusnot on this mapstarted 2024, after this paper: background citation

Combination of 0.09% Cyclosporine and Intense Pulsed Light (IPL) Therapy for the Treatment of Dry Eye Disease in Symptomatic Contact Lens Wearers: a Sham-Controlled Randomized Clinical Trial

TypeinterventionalSponsorUniversité de SherbrookeRan2024 to 2025Enrolled44ConditionsDry Eye, Contact Lens ComplicationArmsCycloSPORINE Ophthalmic, Intense Pulsed Light, Sham Intense Pulse Light
3 · Its place in the literature

Who cites it

206 citing papers in PubMed, 5 syntheses or guidelines pooled it, 358 citations in OpenAlex.

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  17. Diurnal Variation of Tear and Meibum Lipids in Healthy Subjects.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
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146 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Priyanka ChhadvaDepartment of Ophthalmology, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois.
Raquel GoldhardtBascom Palmer Eye Institute, Miami, Florida; Miami Veterans Administration Medical Center, Miami, Florida.
Anat GalorBascom Palmer Eye Institute, Miami, Florida; Miami Veterans Administration Medical Center, Miami, Florida. Electronic address: AGalor@med.miami.edu.
University of Illinois Chicago · US

Funding

Shared Equipment ModuleP30EY014801 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Abigail S Hackam · 2004 to 2026
$12.2M
Dry Eye and MicroenvironmentR01EY026174 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GALOR, ANAT, KUMAR, NARESH · 2016 to 2020
$1.9M
NEUROPATHIC PAIN: A CRITICAL MISSING PIECE IN DRY EYE?I01CX001089 · VA · MIAMI VA HEALTH CARE SYSTEM · PI GALOR, ANAT · 2016 to 2019
–
BLRD VA I01 BX004893CSRD VA I01 CX001089NEI NIH HHS P30 EY014801NEI NIH HHS R01 EY026174
6 · The paper itself

Abstract

topicTo discuss the pathology, causes, and ocular surface impact of meibomian gland disease (MGD), as well as its relationship to dry eye. CLINICAL RELEVANCE: MGD is a common disorder with various contributing mechanisms and clinical manifestations. Understanding MGD pathophysiology and its relationship to dry eye is important in order to optimize diagnosis and treatment algorithms.

methodsA review of current literature was performed to discern MGD in terms of pathophysiology, risk factors, and ocular surface impact, and the relationship to dry eye.

resultsMeibomian gland obstruction and meibocyte depletion are important components of MGD. Many pathologies can disrupt function of meibomian glands, ranging from congenital to acquired causes. Once gland disruption occurs, the quality and quantity of meibum is altered, with a negative impact on the ocular surface. Increased tear evaporation, tear hyperosmolarity, increased ocular surface staining, increased inflammation, symptomatic irritation of the eyelid and globes, as well as decreased visual acuity have all been observed.

conclusionMGD leads to changes in meibum quality and quantity that can cause evaporative dry eye and ocular surface disruption, leading to dry eye symptoms in some individuals.

Indexed as

AnimalsDry Eye SyndromesEyelid DiseasesHumansMeibomian Glands

Identifiers

PMID29055358
PMCPMC5685175
OpenAlexW2767073127

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.