Evidence map›Paper›PMID 29055006›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2017

Posttranscriptional Regulation of HLA-A Protein Expression by Alternative Polyadenylation Signals Involving the RNA-Binding Protein Syncrip.

Smita Kulkarni, Veron Ramsuran, Marijana Rucevic, Sukhvinder Singh, Alexandra Lied, Viraj Kulkarni, Colm O'hUigin, Sylvie Le Gall, Mary Carrington

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
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  8. Maintenance of Hypoimmunogenic FeaturesFrontiers in bioengineering and biotechnology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Smita KulkarniRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139; skulkarni@txbiomed.org.
Veron RamsuranRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139.ORCID 0000-0003-1590-9893
Marijana RucevicRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139.
Sukhvinder SinghDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, TX 78227.
Alexandra LiedRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139.
Viraj KulkarniRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139.
Colm O'hUiginCancer and Inflammation Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702.
Sylvie Le GallRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139.
Mary CarringtonRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139.ORCID 0000-0002-2692-2180
Leidos (United States) · USRagon Institute of MGH, MIT and Harvard · USTexas Biomedical Research Institute · US

Funding

Effects of genetic polymorphism in MHC, KIR, and related loci on human diseaseZIABC010791 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CARRINGTON, MARY N. · 2009 to 2025
$18.2M
Tuberculosis and T cell RecognitionR01AI123286 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BEHAR, SAMUEL M, FORTUNE, SARAH · 2016 to 2020
$3.5M
CCR NIH HHS HHSN261200800001CIntramural NIH HHS ZIA BC010791NCI NIH HHS HHSN261200800001ENIAID NIH HHS R01 AI123286
6 · The paper itself

Abstract

Genomic variation in the untranslated region (UTR) has been shown to influence HLA class I expression level and associate with disease outcomes. Sequencing of the 3'UTR of common

Indexed as

3' Untranslated RegionsGene Expression RegulationGenotypeHeterogeneous-Nuclear RibonucleoproteinsHLA-A AntigensHumansJurkat CellsPolyadenylationPolymorphism, GeneticProtein BindingProtein IsoformsRNA-Binding MotifsRNA Processing, Post-TranscriptionalRNA, Small InterferingRNA Splice Sites3' Untranslated RegionsHeterogeneous-Nuclear RibonucleoproteinsHLA-A AntigensProtein IsoformsRNA, Small InterferingRNA Splice SitesSYNCRIP protein, human

Identifiers

PMID29055006
PMCPMC5812486
OpenAlexW2765129625

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.