Evidence map›Paper›PMID 29055004›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2017

STAT4 Regulates the CD8

Parésa L Taghavie-Moghadam, Tayab C Waseem, Julian Hattler, Lindsey M Glenn, Anca D Dobrian, Mark H Kaplan, Yi Yang, Roza Nurieva, Jerry L Nadler, Elena V Galkina

Open access · greenAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. An angel or a devil? Current view on the role of CD8Journal of translational medicine · 2024
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. The diagnostic role of PD-1Journal of clinical laboratory analysis · 2022
    Article
  10. Harnessing CD8Cells · 2021
    Review
  11. Article
  12. Review
  13. CD8Frontiers in immunology · 2021
    Review
  14. Article
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Parésa L Taghavie-MoghadamDepartment of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23501.
Tayab C WaseemDepartment of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23501.
Julian HattlerDepartment of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23501.
Lindsey M GlennStrelitz Diabetes Center, Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, VA 23507.ORCID 0000-0002-8543-6684
Anca D DobrianDepartment of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA 23501.
Mark H KaplanDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202.ORCID 0000-0002-2923-8245
Yi YangDepartment of Radiation Oncology, The Second Hospital of Jilin University Changchun, Changchun 130041, People's Republic of China; and.
Roza NurievaDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.ORCID 0000-0002-8483-1121
Jerry L NadlerStrelitz Diabetes Center, Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, VA 23507; galkinev@evms.edu nadlerjl@evms.edu.
Elena V GalkinaDepartment of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23501; galkinev@evms.edu nadlerjl@evms.edu.
Eastern Virginia Medical School · USThe University of Texas MD Anderson Cancer Center · USIndiana University – Purdue University Indianapolis · US

Funding

STAT4 IMMUNOLOGYR01AI045515 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI KAPLAN, MARK H · 1999 to 2014
$4.3M
Role of the Interleukin12/STAT4 Pathway in Insulin Resistance and AtherosclerosisR01HL112605 · NHLBI · EASTERN VIRGINIA MEDICAL SCHOOL · PI NADLER, JERRY L. · 2012 to 2016
$2.0M
T cell plasticity in atherosclerosisR01HL107522 · NHLBI · EASTERN VIRGINIA MEDICAL SCHOOL · PI GALKINA, ELENA V · 2011 to 2015
$1.8M
STAT1: New regulator of inflammatory Th17 and Th2 cellsR21AI120012 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI NURIEVA, ROZA INSAFETDINOVNA · 2016 to 2017
$440k
Role of Grail in maintaining humoral immune toleranceR03AI120027 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI NURIEVA, ROZA INSAFETDINOVNA · 2015 to 2016
$160k
NHLBI NIH HHS R01 HL107522NHLBI NIH HHS R01 HL112605NIAID NIH HHS R01 AI045515NIAID NIH HHS R03 AI120027NIAID NIH HHS R21 AI120012
6 · The paper itself

Abstract

The metabolic syndrome and diabetic conditions support atherosclerosis, but the exact mechanisms for accelerated atherogenesis remain unclear. Although the proinflammatory role of STAT4 in atherosclerosis and diet-induced insulin resistance (IR) was recently established, the impact of STAT4 on atherogenesis in conditions of IR is not known. In this study, we generated

Indexed as

AnimalsAtherosclerosisCD8 AntigensCells, CulturedCholesterolDiet, AtherogenicGerminal CenterHumansInsulin ResistanceLymphocyte ActivationMaleMiceMice, Inbred C57BLMice, KnockoutReceptors, LDLSTAT4 Transcription FactorCD8 AntigensCholesterolReceptors, LDLStat4 protein, mouseSTAT4 Transcription Factor

Identifiers

PMID29055004
PMCPMC5675741
OpenAlexW2766464900

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.