ArticleCirculation2017
Radiation-Induced DNA Damage in Operators Performing Endovascular Aortic Repair.
Article in Circulation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04513613 (A Post-Market Registry for the Evaluation of the CorPath® GRX System Effectiveness in Peripheral Vascular Interventions), which is not on this map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Post-Market Registry for the Evaluation of the CorPath® GRX System Effectiveness in Peripheral Vascular Interventions
Who cites it
32 citing papers in PubMed, 132 citations in OpenAlex.
- Antioxidant premedication reduces mitochondrial and nuclear DNA damage repair in interventional physicians performing X-ray-guided angiography procedures: a pilot clinical intervention study.CVIR endovascular · 2026Article
- Occupational Pelvic and Chest-Level Radiation Exposure Among Interventional Echocardiographers During Percutaneous Structural Heart Interventions.JACC. Advances · 2026Article
- Article
- An Optimized Ultra-Low-Dose Imaging Protocol for Endovascular Aortic Repair Significantly Reduces Radiation and Contrast Exposures.Journal of clinical medicine · 2026Article
- Nature-inspired confined cascade enzyme nanoreactors for targeted atherosclerosis therapy.Signal transduction and targeted therapy · 2026Article
- Radiation Realities: Radiation Safety Practices and Awareness Among Interventional Echocardiographers in the United States.Structural heart : the journal of the Heart Team · 2026Article
- Radiation Exposure for Interventional Pain Management Physicians: A Review of Recent Literature.Current pain and headache reports · 2025Review
- Review
- Beyond Uncertainty: Establishing the Oda Strategy for the Treatment of Acute Aortic Dissection.Journal of clinical medicine · 2025Review
- Variability in State-Level Regulations Regarding Occupational Radiation Exposure.Journal of the Society for Cardiovascular Angiography & Interventions · 2025Article
- Robotic radiation shielding system reduces radiation-induced DNA damage in operators performing electrophysiological procedures.Scientific reports · 2025Article
- Lucerne milestone approach for benchmarking and education: Towards ultra-low dose endovascular aortic repair.Journal of vascular surgery cases and innovative techniques · 2025Article
- Potential biomarkers of chronic low-dose radiation exposure for nuclear medicine technologists.International journal of radiation biology · 2025Review
- Concept, Design, and Preclinical Testing of a Remote-Control Robotic System for Transesophageal Echocardiography.Structural heart : the journal of the Heart Team · 2024Article
- The effect of Fiber Optic RealShape technology on the reduction of radiation during complex endovascular surgery.Journal of vascular surgery · 2024Article
- Radiation Doses to the Entire Catheterization Laboratory Team With a Novel Radiation Protection Device.Journal of the Society for Cardiovascular Angiography & Interventions · 2024Article
- Robotically-assisted neuro-endovascular procedures: Single-Center Experience and a Review of the Literature.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2023Review
- Use of surgical augmented intelligence maps can reduce radiation and improve safety in the endovascular treatment of complex aortic aneurysms.Journal of vascular surgery · 2023Article
- Fluoroscopically guided vascular and cardiac transcatheter procedures: a comparison of occupational and patient dose by anatomical region.Physical and engineering sciences in medicine · 2023Observational
- A comparison of patient dose and occupational eye dose to the operator and nursing staff during transcatheter cardiac and endovascular procedures.Scientific reports · 2023Article
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Authors and funding
10 authors at 6 institutions in 4 countries.
Funding
Abstract
backgroundRadiation exposure during fluoroscopically guided interventions such as endovascular aortic repair (EVAR) is a growing concern for operators. This study aimed to measure DNA damage/repair markers in operators perfoming EVAR.
methodsExpression of the DNA damage/repair marker, γ-H2AX and DNA damage response marker, phosphorylated ataxia telangiectasia mutated (pATM), were quantified in circulating lymphocytes in operators during the peri-operative period of endovascular (infrarenal, branched, and fenestrated) and open aortic repair using flow cytometry. These markers were separately measured in the same operators but this time wearing leg lead shielding in addition to upper body protection and compared with those operating with unprotected legs. Susceptibility to radiation damage was determined by irradiating operators' blood in vitro.
resultsγ-H2AX and pATM levels increased significantly in operators immediately after branched endovascular aortic repair/fenestrated endovascular aortic repair (
conclusionsThis is the first study to detect an acute DNA damage response in operators performing fluoroscopically guided aortic procedures and highlights the protective effect of leg shielding. Defining the relationship between this response and cancer risk may better inform safe levels of chronic low-dose radiation exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.