ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Common Synaptic Input to Motor Neurons and Neural Drive to Targeted Reinnervated Muscles.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 45 citations in OpenAlex.
- Sensing and decoding the neural drive to paralyzed muscles during attempted movements of a person with tetraplegia using a sleeve array.Journal of neurophysiology · 2021Trial
- Low-dose hip abductor-adductor power training improves neuromechanical weight-transfer control during lateral balance recovery in older adults.Clinical biomechanics (Bristol, Avon) · 2018Trial
- Analysis of motor units with high-density surface electromyography: methodological considerations and physiological significance.European journal of applied physiology · 2026Review
- Targeted Muscle Reinnervation-an Up-to-Date Review: Evidence, Indications, and Technique.Archives of plastic surgery · 2025Article
- Treatment of Phantom and Residual Limb Pain in Amputees With Targeted Muscle Reinnervation.Eplasty · 2025Article
- Acute modulation of common synaptic inputs and motor unit discharge rates following neuromuscular electrical stimulation superimposed onto voluntary contractions.Frontiers in physiology · 2025Article
- Integrated Transcriptomics and Network Analysis Identified Altered Neural Mechanisms in Frontal Aging Brain-Associated Alzheimer's Disease.Biochemical genetics · 2024Article
- Mapping of spastic muscle activity after stroke: difference between passive stretch and active contraction.Journal of neuroengineering and rehabilitation · 2024Article
- Essential Tremor accentuates the pattern of tremor-band coherence between upper-limb muscles.Journal of neurophysiology · 2023Article
- Failure to improve task performance after visuomotor training with error reduction feedback for young adults.Frontiers in physiology · 2023Article
- Experimental nerve transfer model in the neonatal rat.Neural regeneration research · 2022Article
- Failed Targeted Muscle Reinnervation: Findings at Revision Surgery and Concepts for Success.Plastic and reconstructive surgery. Global open · 2022Article
- In-silico development and assessment of a Kalman filter motor decoder for prosthetic hand control.Computers in biology and medicine · 2021Article
- Gesture Recognition Using Surface Electromyography and Deep Learning for Prostheses Hand: State-of-the-Art, Challenges, and Future.Frontiers in neuroscience · 2021Review
- Spinal motoneurons of the human newborn are highly synchronized during leg movements.Science advances · 2020Article
- Fixed muscle synergies and their potential to improve the intuitive control of myoelectric assistive technology for upper extremities.Journal of neuroengineering and rehabilitation · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We compared the behavior of motor neurons innervating their physiological muscle targets with motor neurons from the same spinal segment whose axons were surgically redirected to remnant muscles (targeted muscle reinnervation). The objective was to assess whether motor neurons with nonphysiological innervation receive similar synaptic input and could be voluntary controlled as motor neurons with natural innervation. For this purpose, we acquired high-density EMG signals from the biceps brachii in 5 male transhumeral amputees who underwent targeted reinnervation of this muscle by the ulnar nerve and from the first dorsal interosseous muscle of 5 healthy individuals to investigate the natural innervation of the ulnar nerve. The same recordings were also performed from the biceps brachii muscle of additional 5 able-bodied individuals. The EMG signals were decomposed into discharges of motor unit action potentials. Motor neurons were progressively recruited for the full range of submaximal muscle activation in all conditions. Moreover, their discharge rate significantly increased from recruitment to target activation level in a similar way across the subject groups. Motor neurons across all subject groups received common synaptic input as identified by coherence analysis of their spike trains. However, the relative strength of common input in both the delta (0.5-5 Hz) and alpha (5-13 Hz) bands was significantly smaller for the surgically reinnervated motor neuron pool with respect to the corresponding physiologically innervated one. The results support the novel approach of motor neuron interfacing for prosthesis control and provide new insights into the role of afferent input on motor neuron activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.