Evidence map›Paper›PMID 29054845›Full record

ArticleJournal of the American Heart Association2017

Does Moderate Drinking Increase the Risk of Atrial Fibrillation? The Norwegian HUNT (Nord-Trøndelag Health) Study.

Katalin Gémes, Vegard Malmo, Lars Erik Laugsand, Jan Pål Loennechen, Hanne Ellekjaer, Krisztina D László, Staffan Ahnve, Lars J Vatten, Kenneth J Mukamal, Imre Janszky

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Alcohol consumption and risk of atrial fibrillation: a pairwise and network meta-analysis.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Pooled it
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  8. Atrial fibrillation and stroke prevention: 25 years of research at EP Europace journal.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Review
  9. Alcohol and Cardiac Arrythmias: A Review of the Current Data.Reviews in cardiovascular medicine · 2023
    Review
  10. Article
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  15. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2021
    Article
  16. Article
  17. Article
  18. Lifestyle modification for the management of atrial fibrillation.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2020
    Article
  19. Review
  20. Diet for stroke prevention.Stroke and vascular neurology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Katalin GémesDepartment of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden katalin.gemes@ki.se imre.janszky@ntnu.no.
Vegard MalmoDepartment of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Lars Erik LaugsandDepartment of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Jan Pål LoennechenDepartment of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Hanne EllekjaerDepartment of Neuroscience and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
Krisztina D LászlóDepartment of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
Staffan AhnveDepartment of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
Lars J VattenDepartment of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Kenneth J MukamalDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, MA.
Imre JanszkyDepartment of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway katalin.gemes@ki.se imre.janszky@ntnu.no.
Norwegian University of Science and Technology · NOKarolinska Institutet · SESt Olav's University Hospital · NOBeth Israel Deaconess Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCompelling evidence suggests that excessive alcohol consumption increases the risk of atrial fibrillation (AF), but the effect of light-moderate alcohol consumption is less certain. We investigated the association between alcohol consumption within recommended limits and AF risk in a light-drinking population. METHODS AND

resultsAmong 47 002 participants with information on alcohol consumption in a population-based cohort study in Norway, conducted from October 2006 to June 2008, 1697 validated AF diagnoses were registered during the 8 years of follow-up. We used Cox proportional hazard models with fractional polynomials to analyze the association between alcohol intake and AF. Population attributable risk for drinking within the recommended limit (ie, at most 1 drink per day for women and 2 drinks per day for men without risky drinking) compared with nondrinking was also calculated. The average alcohol intake was 3.8±4.8 g/d. The adjusted hazard ratio for AF was 1.38 (95% confidence interval, 1.06-1.80) when we compared participants consuming >7 drinks per week with abstainers. When we modeled the quantity of alcohol intake as a continuous variable, the risk increased in a curvilinear manner. It was higher with heavier alcohol intake, but there was virtually no association at <1 drink per day for women and <2 drinks per day for men in the absence of risky drinking. The population attributable risk among nonrisky drinkers was 0.07% (95% confidence interval, -0.01% to 0.13%).

conclusionsAlthough alcohol consumption was associated with a curvilinearly increasing risk of AF in general, the attributable risk of alcohol consumption within recommended limits among participants without binge or problem drinking was negligible in this population.

Indexed as

Life StyleAdultAgedAlcohol DrinkingAtrial FibrillationChi-Square DistributionFemaleHealth SurveysHumansMaleMiddle AgedMultivariate AnalysisNonlinear DynamicsNorwayProportional Hazards ModelsRisk Assessmentalcoholatrial fibrillationcohort studyepidemiologyHUNTmoderate alcohol

Identifiers

PMID29054845
PMCPMC5721892
OpenAlexW2767002255

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.