ArticleJournal of the American Heart Association2017
Contribution of Extra-Cardiac Cells in Murine Heart Valves is Age-Dependent.
Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 61 citations in OpenAlex.
- Rapid endothelialization of printed vascular grafts by perivascular niche-circulating endothelial progenitors crosstalk.Nature communications · 2025Article
- Unveiling the intricacies of cardiac valve pathophysiology.Frontiers in cardiovascular medicine · 2025Review
- Multiscale structure and function of the aortic valve apparatus.Physiological reviews · 2024Review
- WGCNA and molecular docking identify hub genes for cardiac aging.Frontiers in cardiovascular medicine · 2023Article
- Macrophage-extracellular matrix interactions: Perspectives for tissue engineered heart valve remodeling.Frontiers in cardiovascular medicine · 2022Review
- Tgfβ1-Cthrc1 Signaling Plays an Important Role in the Short-Term Reparative Response to Heart Valve Endothelial Injury.Arteriosclerosis, thrombosis, and vascular biology · 2021Article
- Inflammatory and Biomechanical Drivers of Endothelial-Interstitial Interactions in Calcific Aortic Valve Disease.Circulation research · 2021Review
- Macrophage lineages in heart valve development and disease.Cardiovascular research · 2021Review
- The Endocardium and Heart Valves.Cold Spring Harbor perspectives in biology · 2020Review
- Secreted Factors From Proinflammatory Macrophages Promote an Osteoblast-Like Phenotype in Valvular Interstitial Cells.Arteriosclerosis, thrombosis, and vascular biology · 2020Article
- New Concepts in the Development and Malformation of the Arterial Valves.Journal of cardiovascular development and disease · 2020Review
- Macrophages Promote Aortic Valve Cell Calcification and Alter STAT3 Splicing.Arteriosclerosis, thrombosis, and vascular biology · 2020Article
- Adaptive immune cells in calcific aortic valve disease.American journal of physiology. Heart and circulatory physiology · 2019Review
- Maturation of heart valve cell populations during postnatal remodeling.Development (Cambridge, England) · 2019Article
- Calcific Aortic Valve Disease: a Developmental Biology Perspective.Current cardiology reports · 2018Review
- Monocytes and Macrophages in Heart Valves: Uninvited Guests or Critical Performers?Current opinion in biomedical engineering · 2018Article
- The Genetic Regulation of Aortic Valve Development and Calcific Disease.Frontiers in cardiovascular medicine · 2018Review
- Article
- Contribution of Extra-Cardiac Cells in Murine Heart Valves is Age-Dependent.Journal of the American Heart Association · 2017Article
- Significance of inflammation-related markers and histopathological features in mitral valve regurgitation.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundHeart valves are dynamic structures that open and close over 100 000 times a day to maintain unidirectional blood flow during the cardiac cycle. Function is largely achieved by highly organized layers of extracellular matrix that provide the necessary biomechanical properties. Homeostasis of valve extracellular matrix is mediated by valve endothelial and interstitial cell populations, and although the embryonic origins of these cells are known, it is not clear how they are maintained after birth. The goal of this study is to examine the contribution of extracardiac cells to the aortic valve structure with aging using lineage tracing and bone marrow transplantation approaches. METHODS AND
resultsImmunohistochemistry and fate mapping studies using
conclusionsFindings from this study demonstrate that the percentage of CD45-positive extracardiac cells reside within endothelial and interstitial regions of heart valve structures increases with age. In addition, bone transplantation studies show that engraftment is dependent on the age of the donor and age of the tissue environment of the recipient. These studies create a foundation for further work defining the role of extracardiac cells in homeostatic and diseased heart valves.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.