Evidence map›Paper›PMID 29054689›Full record

ArticleClinical breast cancer2018

Breast Cancer Survivorship Care Variations Between Adjuvant Chemotherapy Regimens.

Alexis D Leal, Holly Van Houten, Lindsey Sangaralingham, Rachel A Freedman, Ahmedin Jemal, Heather B Neuman, Tufia C Haddad, Robert W Mutter, Theresa H M Keegan, Sarah S Mougalian and 4 more

Abstract readComparative Study
In one paragraph

Article in Clinical breast cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Follow-up Care for Breast Cancer Survivors.Journal of the National Cancer Institute · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alexis D LealDivision of Medical Oncology, Mayo Clinic, Rochester, MN.
Holly Van HoutenRobert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN; OptumLabs, Cambridge, MA.
Lindsey SangaralinghamRobert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN; OptumLabs, Cambridge, MA.
Rachel A FreedmanDana-Farber Cancer Institute, Boston, MA.
Ahmedin JemalAmerican Cancer Society, Atlanta, GA.
Heather B NeumanWisconsin Surgical Outcomes Research Program, Department of Surgery, University of Wisconsin School of Medicine, Madison, WI.
Tufia C HaddadDivision of Medical Oncology, Mayo Clinic, Rochester, MN.
Robert W MutterDivision of Radiation Oncology, Mayo Clinic, Rochester, MN.
Theresa H M KeeganDivision of Hematology and Oncology, University of California Davis School of Medicine, Sacramento, CA.
Sarah S MougalianCancer Outcomes, Public Policy and Effectiveness Research Center, Yale University, New Haven, CT.
Charles L LoprinziDivision of Medical Oncology, Mayo Clinic, Rochester, MN.
Cary P GrossCancer Outcomes, Public Policy and Effectiveness Research Center, Yale University, New Haven, CT.
Nilay ShahRobert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN; OptumLabs, Cambridge, MA.
Kathryn J RuddyDivision of Medical Oncology, Mayo Clinic, Rochester, MN. Electronic address: ruddy.kathryn@mayo.edu.

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Mayo Clinic Center for Translational Science ActivitiesKL2TR000136 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$6.6M
BUILDING INTERDISCIPLINARY RESEARCH CAREER IN WOMEN'S HEALTH (BIRCWH) SCHOLARSK12HD055894 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI BURNSIDE, ELIZABETH S · 2007 to 2016
$4.1M
NCATS NIH HHS KL2 TR000136NICHD NIH HHS K12 HD055894
6 · The paper itself

Abstract

backgroundTreatment-related toxicity can vary substantially between chemotherapy regimens. In this study we evaluated the frequency of outpatient office visits among a cohort of early stage breast cancer survivors after completion of 4 different adjuvant chemotherapy regimens to better understand how differences in toxicities between regimens might affect health care use. MATERIALS AND

methodsWe analyzed administrative claims data from a US commercial insurance database (OptumLabs) to identify women who received adjuvant doxorubicin/cyclophosphamide (AC), AC followed or preceded by docetaxel or paclitaxel (AC-T), AC concurrent with docetaxel or paclitaxel (TAC), or docetaxel/cyclophosphamide (TC) between 2008 and 2014. We compared mean numbers of visits per patient (adjusted for age, race/ethnicity, region, year, surgery type, radiation, chronic conditions, and previous hospitalizations) across the different regimens (TC = reference) for 12 months, starting 4 months after the end of chemotherapy.

resultsIn 6247 eligible patients, the mean adjusted number of outpatient visits per patient was significantly higher in patients who received AC-T (8.1) or TAC (7.3) than TC (6.5) or AC (6.0; P < .001 for comparisons of AC-T and TAC with TC), primarily because of differences in Medical Oncology visits. Approximately 40% did not see a primary care provider at all during this time frame.

conclusionsAC-T and TAC are associated with more subsequent outpatient visits than TC. Visits to primary care providers are infrequent during the year after completion of chemotherapy.

Indexed as

AdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsBreast NeoplasmsCancer SurvivorsChemotherapy, AdjuvantCohort StudiesCyclophosphamideDocetaxelDoxorubicinFemaleHumansInsurance Claim ReviewLymph Node ExcisionMastectomyCyclophosphamideDocetaxelDoxorubicinPaclitaxelBreast neoplasmsFollow-upHealth care useOutpatientToxicity

Identifiers

PMID29054689
PMCPMC6208362

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.