ArticleDental materials : official publication of the Academy of Dental Materials2018
Collagenous matrix supported by a 3D-printed scaffold for osteogenic differentiation of dental pulp cells.
Article in Dental materials : official publication of the Academy of Dental Materials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Biofabrication for complex tissue regeneration: a scoping review of translational gaps in craniomaxillofacial reconstruction.Frontiers in oral health · 2026Review
- Biocompatibility Evaluation of Surface-Modified Orthodontic Wires Using Graphene Layer.International journal of molecular sciences · 2025Article
- 3D-Printed Cell-Instructive Scaffolds Based onACS biomaterials science & engineering · 2025Article
- Promoting Angiogenesis/Osteogenesis by a New Copper/Magnesium Hydroxide Hybrid Nanoparticle: In Vitro and In Vivo Investigation.Journal of biomedical materials research. Part A · 2025Article
- Applications and interventions of polymers and nanomaterials in alveolar bone regeneration and tooth dentistry.RSC advances · 2024Review
- Recent advances in additive manufacturing of patient-specific devices for dental and maxillofacial rehabilitation.Dental materials : official publication of the Academy of Dental Materials · 2024Review
- The 3-dimensional printing for dental tissue regeneration: the state of the art and future challenges.Frontiers in bioengineering and biotechnology · 2024Review
- Regeneration of Critical-Sized Mandibular Defects Using 3D-Printed Composite Scaffolds: A Quantitative Evaluation of New Bone Formation in In Vivo Studies.Advanced healthcare materials · 2023Review
- Self-assembling peptide-laden electrospun scaffolds for guided mineralized tissue regeneration.Dental materials : official publication of the Academy of Dental Materials · 2022Article
- Synthetic materials in craniofacial regenerative medicine: A comprehensive overview.Frontiers in bioengineering and biotechnology · 2022Review
- Innovations in Craniofacial Bone and Periodontal Tissue Engineering - From Electrospinning to Converged Biofabrication.International materials reviews · 2022Article
- Biomaterial and Biofilm Interactions with the Pulp-Dentin Complex-on-a-Chip.Journal of dental research · 2021Article
- Bioinspired mineralized collagen scaffolds for bone tissue engineering.Bioactive materials · 2021Review
- Biocompatibility of a HA/β-TCP/C Scaffold as a Pulp-Capping Agent for Vital Pulp Treatment: An In Vivo Study in Rat Molars.International journal of environmental research and public health · 2021Article
- Microfluidic fabrication of microcarriers with sequential delivery of VEGF and BMP-2 for bone regeneration.Scientific reports · 2020Article
- Enhancing cell seeding and osteogenesis of MSCs on 3D printed scaffolds through injectable BMP2 immobilized ECM-Mimetic gel.Dental materials : official publication of the Academy of Dental Materials · 2019Article
- Recycle the dental fairy's package: overview of dental pulp stem cells.Stem cell research & therapy · 2018Review
- Thermally induced self-agglomeration 3D scaffolds with BMP-2-loaded core-shell fibers for enhanced osteogenic differentiation of rat adipose-derived stem cells.International journal of nanomedicine · 2018Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
Abstract
objectiveA systematic characterization of hybrid scaffolds, fabricated based on combinatorial additive manufacturing technique and freeze-drying method, is presented as a new platform for osteoblastic differentiation of dental pulp cells (DPCs).
methodsThe scaffolds were consisted of a collagenous matrix embedded in a 3D-printed beta-tricalcium phosphate (β-TCP) as the mineral phase. The developed construct design was intended to achieve mechanical robustness owing to 3D-printed β-TCP scaffold, and biologically active 3D cell culture matrix pertaining to the Collagen extracellular matrix. The β-TCP precursor formulations were investigated for their flow-ability at various temperatures, which optimized for fabrication of 3D printed scaffolds with interconnected porosity. The hybrid constructs were characterized by 3D laser scanning microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, and compressive strength testing.
resultsThe in vitro characterization of scaffolds revealed that the hybrid β-TCP/Collagen constructs offer superior DPCs proliferation and alkaline phosphatase (ALP) activity compared to the 3D-printed β-TCP scaffold over three weeks. Moreover, it was found that the incorporation of TCP into the Collagen matrix improves the ALP activity. SIGNIFICANCE: The presented results converge to suggest the developed 3D-printed β-TCP/Collagen hybrid constructs as a new platform for osteoblastic differentiation of DPCs for craniomaxillofacial bone regeneration.
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Registered trials
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