Evidence map›Paper›PMID 29054555›Full record

ArticleLancet (London, England)2018

Evidence-based guidelines for supportive care of patients with Ebola virus disease.

François Lamontagne, Robert A Fowler, Neill K Adhikari, Srinivas Murthy, David M Brett-Major, Michael Jacobs, Timothy M Uyeki, Constanza Vallenas, Susan L Norris, William A Fischer and 23 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lancet (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Use of Ebola Vaccine: Recommendations of the Advisory Committee on Immunization Practices, United States, 2020.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2021
    Guideline
  5. A systematic review and meta-analysis of patient data from the West Africa (2013-16) Ebola virus disease epidemic.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2019
    Pooled it
  6. Pooled it
  7. Trial
  8. Marburg and Sudan virus outbreaks: are we any closer to a pan-filovirus vaccine?Tropical diseases, travel medicine and vaccines · 2026
    Review
  9. Review
  10. Review
  11. Vaccines for preventing Ebola virus disease.The Cochrane database of systematic reviews · 2024
    Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

33 authors.

François LamontagneDepartment of Medicine, Université de Sherbrooke, Sherbrooke, QC, Canada; Centre de recherche du CHUS de Sherbrooke, Sherbrooke, QC, Canada. Electronic address: francois.lamontagne@usherbrooke.ca.
Robert A FowlerDepartment of Medicine, Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Department of Critical Care Medicine and Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Neill K AdhikariDepartment of Medicine, Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Department of Critical Care Medicine and Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Srinivas MurthyDepartment of Paediatrics, University of British Columbia, Vancouver, BC, Canada.
David M Brett-MajorUS Military HIV Research Program, Henry M. Jackson Foundation, Bethesda, MD, USA.
Michael JacobsRoyal Free London NHS Foundation Trust, London, UK.
Timothy M UyekiUS Centers for Disease Control and Prevention, Atlanta, GA, USA.
Constanza VallenasWorld Health Organization, Geneva, Switzerland.
Susan L NorrisWorld Health Organization, Geneva, Switzerland.
William A FischerDivision of Pulmonary and Critical Care Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Thomas E FletcherLiverpool School of Tropical Medicine, Liverpool, UK.
Adam C LevineEbola Research Team, International Medical Corps, Washington, DC, USA; Department of Emergency Medicine, Warren Alpert Medical School, Providence, RI, USA.
Paul ReedCenter for Global Health Engagement-Uniformed Services University of the Health Sciences, Bethesda, MD, USA; US Public Health Service, Rockville, MD, USA.
Daniel G BauschWorld Health Organization, Geneva, Switzerland; Tulane School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Sandy GoveIntegrated Management of Adolescent and Adult Illness-Integrated Management of Childhood Illness) Alliance, San Francisco, CA, USA.
Andrew HallLondon, UK.
Susan ShepherdAlliance for International Medical Action, Dakar, Senegal.
Reed A SiemieniukDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Marie-Claude LamahDoctors Without Borders, Conakry, Guinea.
Rashida KamaraMinistry of Health and Sanitation, Freetown, Sierra Leone.
Phiona NakyeyuneLondon School of Hygiene & Tropical Medicine, London, UK.
Moses J SokaMinistry of Health, Monrovia, Liberia.
Ama EdwinPalliative Care Service, Korle Bu Teaching Hospital, Accra, Ghana; Ghana Health Service Ethical Review Committee, Accra, Ghana.
Afeez A HazzanDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada; Department of Healthcare Studies, The College at Brockport, State University of New York, NY, USA.
Shevin T JacobDivision of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA, USA.
Mubarak Mustafa ElkarsanyKarary University, Khartoum, Sudan.
Takuya AdachiDepartment of Infectious Diseases, Toshima Hospital, Tokyo, Japan.
Lynda BenhadjDepartment of Community Health Sciences, Université de Sherbrooke, Sherbrooke, Canada; Centre de recherche, Hôpital Charles-Le Moyne, Longueuil, QC, Canada.
Christophe ClémentPolyclinique Bordeaux Nord Aquitaine, Bordeaux, France.
Ian CrozierInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Armando GarciaDoctors Without Borders, Geneva, Switzerland.
Steven J HoffmanDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada; Global Strategy Lab, Dahdaleh Institute for Global Health Research, Faculty of Health, and Osgoode Hall Law School, York University, Toronto, ON, Canada.
Gordon H GuyattDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada.

Funding

Intramural CDC HHS CC999999World Health Organization 001
6 · The paper itself

Abstract

The 2013-16 Ebola virus disease outbreak in west Africa was associated with unprecedented challenges in the provision of care to patients with Ebola virus disease, including absence of pre-existing isolation and treatment facilities, patients' reluctance to present for medical care, and limitations in the provision of supportive medical care. Case fatality rates in west Africa were initially greater than 70%, but decreased with improvements in supportive care. To inform optimal care in a future outbreak of Ebola virus disease, we employed the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology to develop evidence-based guidelines for the delivery of supportive care to patients admitted to Ebola treatment units. Key recommendations include administration of oral and, as necessary, intravenous hydration; systematic monitoring of vital signs and volume status; availability of key biochemical testing; adequate staffing ratios; and availability of analgesics, including opioids, for pain relief.

Indexed as

Disease OutbreaksAfrica, WesternDisease ManagementEvidence-Based MedicineHealth FacilitiesHemorrhagic Fever, EbolaHospitalizationHumansMonitoring, PhysiologicPain ManagementPatient Acceptance of Health CarePractice Guidelines as Topic

Identifiers

PMID29054555
PMCPMC6636325

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.