Evidence map›Paper›PMID 29054476›Full record

ReviewBiochimica et biophysica acta. Reviews on cancer2017

Extracellular vesicles as emerging targets in cancer: Recent development from bench to bedside.

Kerui Wu, Fei Xing, Shih-Ying Wu, Kounosuke Watabe

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biochimica et biophysica acta. Reviews on cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed, 2 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 2 syntheses or guidelines pooled it, 151 citations in OpenAlex.

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42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kerui WuDepartments of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC, USA.
Fei XingDepartments of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC, USA.
Shih-Ying WuDepartments of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC, USA.
Kounosuke WatabeDepartments of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC, USA. Electronic address: kwatabe@wakehealth.edu.
Wake Forest University · US

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
Roles of hyaluronic acid in cancer stem cell nicheR01CA173499 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WATABE, KOUNOSUKE · 2014 to 2018
$2.3M
Roles of long-non-coding RNA, XIST, in brain metastasis of breast cancerR01CA205067 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WATABE, KOUNOSUKE · 2017 to 2021
$2.2M
Role of inflammation and microRNA network in brain metastasis of breast cancerR01CA185650 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WATABE, KOUNOSUKE · 2016 to 2020
$1.9M
NCI NIH HHS P30 CA012197NCI NIH HHS R01 CA173499NCI NIH HHS R01 CA185650NCI NIH HHS R01 CA205067
6 · The paper itself

Abstract

Extracellular vesicles (EVs) have emerged as important players of cancer initiation and progression through cell-cell communication. They have been recognized as critical mediators of extracellular communications, which promote transformation, growth invasion, and drug-resistance of cancer cells. Interestingly, the secretion and uptake of EVs are regulated in a more controlled manner than previously anticipated. EVs are classified into three groups, (i) exosomes, (ii) microvesicles (MVs), and (iii) apoptotic bodies (ABs), based on their sizes and origins, and novel technologies to isolate and distinguish these EVs are evolving. The biologically functional molecules harbored in these EVs, including nucleic acids, lipids, and proteins, have been shown to induce key signaling pathways in both tumor and tumor microenvironment (TME) cells for exacerbating tumor development. While tumor cell-derived EVs are capable of reprogramming stromal cells to generate a proper tumor cell niche, stromal-derived EVs profoundly affect the growth, resistance, and stem cell properties of tumor cells. This review summarizes and discusses these reciprocal communications through EVs in different types of cancers. Further understanding of the pathophysiological roles of different EVs in tumor progression is expected to lead to the discovery of novel biomarkers in liquid biopsy and development of tumor specific therapeutics. This review will also discuss the translational aspects of EVs and therapeutic opportunities of utilizing EVs in different cancer types.

Indexed as

AnimalsBiomarkersCell CommunicationCell SeparationExomeExtracellular VesiclesHumansMesenchymal Stem CellsMicroRNAsNeoplasmsProtein TransportSignal TransductionTumor MicroenvironmentBiomarkersMicroRNAsApoptotic bodyCancerExosomeExtracellular vesiclesMicrovesicleTranslational studies

Identifiers

PMID29054476
PMCPMC5675795
OpenAlexW2765293311

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.