ArticleJournal of controlled release : official journal of the Controlled Release Society2017
Ragweed pollen as an oral vaccine delivery system: Mechanistic insights.
Article in Journal of controlled release : official journal of the Controlled Release Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Efficacy of Purified Borrelial Lipoproteins (PBL) as an oral formulation in reducing transmission of Lyme spirochetes from reservoir hosts tobioRxiv : the preprint server for biology · 2026Article
- Article
- Chrysanthemum sporopollenin: A novel vaccine delivery system for nasal mucosal immunity.Frontiers in immunology · 2023Article
- Purification of Hollow Sporopollenin Microcapsules from Sunflower and Chamomile Pollen Grains.Polymers · 2021Article
- Pollens derived magnetic porous particles for adsorption of low-density lipoprotein from plasma.Bioactive materials · 2021Article
- Plant Pollen Grains: A Move Towards Green Drug and Vaccine Delivery Systems.Nano-micro letters · 2021Article
- Review
- Formulations for Allergen Immunotherapy in Human and Veterinary Patients: New Candidates on the Horizon.Frontiers in immunology · 2020Review
- A natural solution to photoprotection and isolation of the potent polyene antibiotic, marinomycin A.Chemical science · 2019Article
- Performance of a glucose-reactive enzyme-based biofuel cell system for biomedical applications.Scientific reports · 2019Article
- Species-Specific Biodegradation of Sporopollenin-Based Microcapsules.Scientific reports · 2019Article
- Mucosal vaccines and technology.Clinical and experimental immunology · 2019Review
- Novel approaches for the design, delivery and administration of vaccine technologies.Clinical and experimental immunology · 2019Review
- Pollen grains as a novel microcarrier for oral delivery of proteins.International journal of pharmaceutics · 2018Article
- The atypically high modulus of pollen exine.Journal of the Royal Society, Interface · 2018Article
- From allergen to oral vaccine carrier: A new face of ragweed pollen.International journal of pharmaceutics · 2018Article
- A chemical treatment method for obtaining clean and intact pollen shells of different species.ACS biomaterials science & engineering · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
We have recently developed pollen grains (PGs) as a unique method to deliver vaccines orally. Extensive chemical processing ensures allergen-free pollen microcapsules that can be loaded with vaccine antigens. Successful oral vaccine delivery has been previously demonstrated by us in a mouse model. However, the underlying mechanisms that help the processed PGs to achieve this goal were not fully understood. In this study, we wanted to understand the effects of chemically processed ragweed pollen (Ambrosia elatior) on the innate immune system. Intestinal epithelial cells, macrophages, and dendritic cells all bridge the innate and adaptive immunity. This study has shown that in response to ragweed pollen all these cells release inflammatory cytokines and chemokines. Scanning electron microscopy imaging revealed that macrophages can engulf ragweed pollen. In addition, in the presence of ragweed, mouse dendritic cells upregulated their activation markers, that is, CD40, CD80, CD86, and MHC class II molecules. Ragweed pollens did not cause significant cell membrane damage as compared to similarly sized poly (lactic-co-glycolic acid) particles. Moreover, ragweed did not affect the integrity of the intestinal epithelial cells. Ragweed pollens were also found in the subepithelial region of the small intestine 24h after pollens were gavaged to mice. Our current findings lead to the conclusion that besides transporting the vaccine cargo, ragweed pollen shells have additional immunomodulatory properties that help the orally delivered antigen to effectively induce an immune response.
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Registered trials
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