Evidence map›Paper›PMID 29054034›Full record

ArticleInfant behavior & development2017

An exploration of common dopaminergic variants and behavior problems in siblings at high risk for autism spectrum disorder.

Devon N Gangi, Lauren V Usher, Daniel S Messinger

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infant behavior & development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Devon N GangiMIND Institute, University of California, Davis, UC Davis Medical Center, 2825 50(th) Street, Sacramento, CA 95817, USA. Electronic address: dngangi@ucdavis.edu.
Lauren V UsherWaisman Center, University of Wisconsin-Madison, 1500 Highland Ave, Madison, WI 53705, USA. Electronic address: usher3@waisman.wisc.edu.
Daniel S MessingerDepartments of Psychology, Pediatrics, Electrical & Computer Engineering, and Music Engineering, University of Miami, 5665 Ponce de Leon Blvd, Coral Gables, FL 33146, USA. Electronic address: dmessinger@miami.edu.
University of Miami · USUniversity of Wisconsin–Madison · US

Funding

Interdisciplinary Training for Autism Researchers(RMI)T32MH073124 · NIMH · UNIVERSITY OF CALIFORNIA DAVIS · PI Stephen Charles Noctor, Christine Wu Nordahl · 2004 to 2026
$6.8M
POSTDOCTORAL TRAINING IN MENTAL RETARDATION RESEARCHT32HD007489 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Sigan L Hartley · 1995 to 2026
$6.0M
Social-Emotional Development of Infants At Risk for Autism SpectrumR01HD057284 · NICHD · VANDERBILT UNIVERSITY · PI MESSINGER, DANIEL S, STONE, WENDY L. · 2008 to 2012
$3.1M
Modeling the Dynamics of Early Communication and DevelopmentR01GM105004 · NIGMS · UNIVERSITY OF MIAMI CORAL GABLES · PI CHOW, SY-MIIN, COHN, JEFFREY F · 2013 to 2016
$2.1M
Emotion, communication, & EEG: Development & riskR01HD047417 · NICHD · UNIVERSITY OF MIAMI CORAL GABLES · PI MESSINGER, DANIEL S · 2006 to 2010
$1.5M
NICHD NIH HHS R01 HD047417NICHD NIH HHS R01 HD057284NICHD NIH HHS T32 HD007489NIGMS NIH HHS R01 GM105004NIMH NIH HHS T32 MH073124
6 · The paper itself

Abstract

Younger siblings of children with ASD often exhibit elevated internalizing and externalizing problems. We investigated common dopaminergic variants (DRD4 and DRD2) in relation to behavior problems at 36 months. Genotypes linked to less efficient dopaminergic functioning were associated with higher internalizing problems in high-risk siblings.

Indexed as

Genetic VariationSiblingsAutism Spectrum DisorderChildFemaleHumansMaleProblem BehaviorReceptors, Dopamine D2Receptors, Dopamine D4Risk AssessmentDRD2 protein, humanDRD4 protein, humanReceptors, Dopamine D2Receptors, Dopamine D4Behavior problemsDopamineHigh-risk siblings

Identifiers

PMID29054034
PMCPMC5716906
OpenAlexW2765766460

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.