ArticlePediatric research2018
Hypoxic renal injury in newborns with abdominal compartment syndrome (clinical and experimental study).
Article in Pediatric research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Comparison of creatinine- and cystatin C-based definitions of acute kidney injury in neonates with congenital diaphragmatic hernia.Pediatric nephrology (Berlin, Germany) · 2026Observational
- Contribution of tissue oximetry to the assessment of renal dysfunction in abdominal compartment syndrome: an experimental canine study.Frontiers in surgery · 2026Article
- Acute Compartment Syndrome and Intra-Abdominal Hypertension, Decompression, Current Pharmacotherapy, and Stable Gastric Pentadecapeptide BPC 157 Solution.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Intra-abdominal hypertension/abdominal compartment syndrome of pediatric patients in critical care settings.Open medicine (Warsaw, Poland) · 2025Review
- Acute kidney injury post-abdominal surgery in infants: implications for prevention and management.Frontiers in pediatrics · 2023Review
- Effects of extensive mobilization and tension anastomosis in anorectal reconstruction (experimental study).Pediatric surgery international · 2022Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BackgroundSurgical treatment for gastroschisis and congenital diaphragmatic hernia (CDH) commonly leads to abdominal compartment syndrome (ACS) associated with hypoxic renal injury. We hypothesized that measurement of urinary and serum concentrations of vascular endothelial growth factor (VEGF), π-glutathione S-transferase (π-GST), and monocyte chemoattractant protein-1 (MCP-1) may serve for noninvasive detection of hypoxic renal injury in such patients.MethodsIntra-abdominal pressure (IAP), renal excretory function, and the biomarker levels were analyzed before, 4, and 10 days after surgery. Association between the biomarker levels and renal histology was investigated using an original model of ACS in newborn rats.ResultsFour days after surgery, IAP increased, renal excretory function decreased, and the levels of VEGF, π-GST, and MCP-1 increased, indicating renal injury. Ten days after surgery, IAP partially decreased, renal excretory function completely restored, but the biomarker levels remained elevated, suggesting the ongoing kidney injury. In the model of ACS, increase in the biomarker levels was associated with progressing kidney morphological alteration.ConclusionSurgical treatment for gastroschisis and CDH is associated with prolonged hypoxic kidney injury despite complete restoration of renal excretory function. Follow-up measurement of VEGF, π-GST, and MCP-1 levels may provide a better tool for noninvasive assessment of renal parenchyma in newborns with ACS.
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