Evidence map›Paper›PMID 29053398›Full record

ReviewCancer biology & therapy2017

The involvement of lncRNAs in the development and progression of pancreatic cancer.

Li Duguang, He Jin, Qian Xiaowei, Xu Peng, Wang Xiaodong, Li Zhennan, Qian Jianjun, Yao Jie

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer biology & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 81 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Li Duguanga The Second Clinical College of Dalian Medical University , 9 Western District, Lvshun South Road, Dalian , Liaoning , P. R. China.
He Jinb Medical college of Yangzhou University , Yangzhou , Jiangsu , P. R. China.
Qian Xiaoweib Medical college of Yangzhou University , Yangzhou , Jiangsu , P. R. China.
Xu Pengc Department of Hepatobiliary and Pancreatic Surgery , Northern Jiangsu People's Hospital, Clinical medical college of Yangzhou University , Yangzhou , Jiangsu , P. R. China.
Wang Xiaodongc Department of Hepatobiliary and Pancreatic Surgery , Northern Jiangsu People's Hospital, Clinical medical college of Yangzhou University , Yangzhou , Jiangsu , P. R. China.
Li Zhennanc Department of Hepatobiliary and Pancreatic Surgery , Northern Jiangsu People's Hospital, Clinical medical college of Yangzhou University , Yangzhou , Jiangsu , P. R. China.
Qian Jianjunc Department of Hepatobiliary and Pancreatic Surgery , Northern Jiangsu People's Hospital, Clinical medical college of Yangzhou University , Yangzhou , Jiangsu , P. R. China.
Yao Jiec Department of Hepatobiliary and Pancreatic Surgery , Northern Jiangsu People's Hospital, Clinical medical college of Yangzhou University , Yangzhou , Jiangsu , P. R. China.ORCID http://orcid.org/0000-0001-5447-893X
Northern Jiangsu People's Hospital · CNYangzhou University · CNDalian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic cancer is one of the most malignant tumors that are difficult to diagnose at its early stage and there is no effective therapy. Recent studies uncovered that many non-protein-coding RNAs including the class of long noncoding RNAs (lncRNAs) are differentially expressed in various types of tumors and they are potent regulators of tumor progression and metastasis. LncRNA can mediate tumor initiation, proliferation, migration and metastasis through modulating epigenetic modification, alternative splicing, transcription, and protein translation. In this review, we discuss the molecular mechanism of lncRNAs in the involvement of tumor growth, survival, epithelial-mesenchymal transition, tumor microenvironment, cancer stem cells and chemoresistance in pancreatic ductal adenocarcinoma (PDAC).

Indexed as

AdenocarcinomaCarcinogenesisCarcinoma, Pancreatic DuctalDisease ProgressionDrug Resistance, NeoplasmEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticHumansNeoplastic Stem CellsRNA, Long NoncodingTumor MicroenvironmentRNA, Long NoncodingCancer Stem CellsChemoresistanceEMTHypoxiaLong-non-coding RNAs (lncRNAs)Pancreatic cancerPancreatic Ductal Adenocarcinoma (PDAC)Tumor Microenvironment

Identifiers

PMID29053398
PMCPMC5718823
OpenAlexW2766424725

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.