Evidence map›Paper›PMID 29053215›Full record

ReviewDiabetes, obesity & metabolism2018

Identification of barriers to insulin therapy and approaches to overcoming them.

David Russell-Jones, Frans Pouwer, Kamlesh Khunti

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Diabetes, obesity & metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04833413 (Effectiveness of Regimen Switch After Intensive Insulin Therapy in Hospitalized Patients With Type 2 Diabetes), which is not on this map. Cited by 128 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
128citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04833413 unknown statusnot on this mapstarted 2021, after this paper: background citation

Effectiveness of Regimen Switch After Intensive Insulin Therapy in Hospitalized Patients With Type 2 Diabetes

TypeobservationalSponsorShanghai Zhongshan HospitalRan2021 to 2024Enrolled1,000ConditionsInsulinArmsContinuous intensive insulin therapy
3 · Its place in the literature

Who cites it

128 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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68 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

David Russell-JonesDepartment of Diabetes and Endocrinology, Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK.
Frans PouwerDepartment of Psychology, University of Southern Denmark, Odense, Denmark.
Kamlesh KhuntiCollege of Medicine, Biological Sciences and Psychology, Leicester Diabetes Centre, University of Leicester, UK.ORCID 0000-0003-2343-7099

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Poor glycaemic control in type 2 diabetes (T2D) is a global problem despite the availability of numerous glucose-lowering therapies and clear guidelines for T2D management. Tackling clinical or therapeutic inertia, where the person with diabetes and/or their healthcare providers do not intensify treatment regimens despite this being appropriate, is key to improving patients' long-term outcomes. This gap between best practice and current level of care is most pronounced when considering insulin regimens, with studies showing that insulin initiation/intensification is frequently and inappropriately delayed for several years. Patient- and physician-related factors both contribute to this resistance at the stages of insulin initiation, titration and intensification, impeding achievement of optimal glycaemic control. The present review evaluates the evidence and reasons for this delay, together with available methods for facilitation of insulin initiation or intensification.

Indexed as

Diabetes Mellitus, Type 2Dose-Response Relationship, DrugHumansHypoglycemic AgentsInsulinPatient Acceptance of Health CareTime-to-TreatmentHypoglycemic AgentsInsulininsulin therapytype 2 diabetes

Identifiers

PMID29053215
PMCPMC5836933

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.