ArticlePsychophysiology2018
Perceived stress is associated with smaller hippocampal volume in adolescence.
Article in Psychophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A meta-analysis of the relation between hippocampal volume and memory ability in typically developing children and adolescents.Hippocampus · 2022Pooled it
- The association of adverse childhood experiences with the progression of chronic kidney disease in children: a CKiD pilot study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Social stress, cortisol awakening response and sex: association with hippocampus and amygdala volume.Biology of sex differences · 2025Article
- Perceived stress mediates the association between orbitofrontal cortex grey matter volume and depressive symptoms in older women.Scientific reports · 2025Article
- Increasing resilience to stress by home-based transcranial stimulation.Research square · 2025Article
- Evidence of Disrupted Hippocampal Gray- and White-Matter Development in Adolescent Anxiety Disorders, Independent From Early-Life Stress.Hippocampus · 2025Article
- The temporal dynamics of perceived stress and depression in college students: An ecological momentary assessment.PsyCh journal · 2025Article
- Inflammation as a shared mechanism of chronic stress related disorders with potential novel therapeutic targets.Naunyn-Schmiedeberg's archives of pharmacology · 2024Review
- Racial discrimination predicts subjective cognitive decline: Perceived relationship support buffers the association.Social science & medicine (1982) · 2024Article
- Racial discrimination during middle age predicts higher serum phosphorylated tau and neurofilament light chain levels a decade later: A study of aging black Americans.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- The Necessity of Taking Culture and Context into Account When Studying the Relationship between Socioeconomic Status and Brain Development.Brain sciences · 2024Review
- Hippocampal Structures Among Japanese Adolescents Before and After the COVID-19 Pandemic.JAMA network open · 2024Article
- The Relationship Between Perceived Stress, Impulsivity, Executive Dysfunction and Non-Suicidal Self-Injury Thoughts Among Chinese College Students: A Gender Difference Study.Psychology research and behavior management · 2024Article
- Direct and Indirect Effects of Socioeconomic Status and Discrimination on Subjective Cognitive Decline: A Longitudinal Study of African American Women.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Article
- Clinical Improvement in Depression and Cognitive Deficit Following Electroconvulsive Therapy.Diagnostics (Basel, Switzerland) · 2023Review
- The times they are a-changin': a proposal on how brain flexibility goes beyond the obvious to include the concepts of "upward" and "downward" to neuroplasticity.Molecular psychiatry · 2023Review
- The Perceived Stress Scale for Kids (PeSSKi): Initial development of a brief measure for children aged 7-11 years.Stress and health : journal of the International Society for the Investigation of Stress · 2023Article
- Positive or negative environmental modulations on human brain development: the morpho-functional outcomes of music training or stress.Frontiers in neuroscience · 2023Review
- The impact of studying on the hippocampal volume in medical students and its correlation with the results of the Final Medical Examination: a single-centre, prospective observational cohort study.Polish journal of radiology · 2023Article
- Homonegative Victimization and Perceived Stress among Adolescent Sexual Minority Males: The Attenuating Role of Peer and Family Support.International journal of sexual health : official journal of the World Association for Sexual Health · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Perceived stress has been associated with decreased hippocampal, amygdala, and prefrontal cortex volume, as well as decreased memory and executive functioning performance in adulthood. Parents' perceived stress has been linked to decreased hippocampal volume in young children. However, no studies have investigated the links between self-perceived stress and brain structure or function in adolescents. Additionally, findings from previous research with younger or older samples are inconsistent, likely in part due to inconsistencies in participants' age range. In this study, we investigated the associations among self-perceived stress, family socioeconomic factors (family income, parental education), subcortical (hippocampus, amygdala) volumes, prefrontal cortical thickness and surface area, and memory and executive functioning performance in adolescents. One hundred and forty-three participants (12-20 years old) were administered a cognitive battery, a questionnaire to assess perceived stress, and a structural MRI scan. Higher levels of perceived stress were associated with decreased adolescent hippocampal volume. This study provides empirical evidence of how experience may shape brain development in adolescence-a period of plasticity during which it may be possible to intervene and prevent negative developmental outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.