ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2018
ADHD, Smoking Withdrawal, and Inhibitory Control: Results of a Neuroimaging Study with Methylphenidate Challenge.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Attention-deficit/hyperactivity disorder and the explore/exploit trade-off.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Trial
- Transcranial Magnetic Stimulation in Smoking Cessation: A Narrative Review of Neurobiological Mechanisms from Craving Modulation to Neural Circuit Restoration.Brain sciences · 2026Review
- Corticostriatal causality analysis in children and adolescents with attention-deficit/hyperactivity disorder.Psychiatry and clinical neurosciences · 2024Article
- Response Inhibition and Interference Control in Adult Attention Deficit Hyperactivity Disorder.Noro psikiyatri arsivi · 2023Article
- Subcortical structures and visual divergent thinking: a resting-state functional MRI analysis.Brain structure & function · 2021Article
- Does methylphenidate use affect sperm parameters in patients undergoing infertility investigation? A retrospective analysis of 9769 semen samples.Archives of gynecology and obstetrics · 2021Article
- A Novel Knowledge Distillation-Based Feature Selection for the Classification of ADHD.Biomolecules · 2021Article
- Associations Between Smoking Abstinence, Inhibitory Control, and Smoking Behavior: An fMRI Study.Frontiers in psychiatry · 2021Article
- Reduced Activation in the Pallidal-Thalamic-Motor Pathway Is Associated With Deficits in Reward-Modulated Inhibitory Control in Adults With a History of Attention-Deficit/Hyperactivity Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
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Authors and funding
8 authors.
Funding
Abstract
Smoking withdrawal negatively impacts inhibitory control, and these effects are greater for smokers with preexisting attention problems, such as attention deficit/hyperactivity disorder (ADHD). The current study preliminarily evaluated changes in inhibitory control-related behavior and brain activation during smoking withdrawal among smokers with ADHD. Moreover, we investigated the role of catecholamine transmission in these changes by examining the effects of 40 mg methylphenidate (MPH) administration. Adult daily smokers with (n=17) and without (n=20) ADHD completed fMRI scanning under each of three conditions: (a) smoking as usual+placebo; (b) 24 h smoking abstinence+placebo and (c) 24 h smoking abstinence+MPH. Scan order was randomized and counterbalanced. Participants completed a modified Go/No-Go task to assess both sustained and transient inhibitory control. Voxelwise analysis of task-related BOLD signal revealed a significant group-by-abstinence interaction in occipital/parietal cortex during sustained inhibition, with greater abstinence-induced decreases in activation observed among ADHD smokers compared with non-ADHD smokers. Changes in behavioral performance during abstinence were associated with changes in activation in regions of occipital and parietal cortex and bilateral insula during sustained inhibition in both groups. MPH administration improved behavioral performance and increased sustained inhibitory control-related activation for both groups. During transient inhibition, MPH increased prefrontal activation for both groups and increased striatal activation only among ADHD smokers. These preliminary findings suggest that abstinence-induced changes in catecholamine transmission in visual attention areas (eg, occipital and superior parietal cortex) may be associated with inhibitory control deficits and contribute to smoking vulnerability among individuals with ADHD.
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