Evidence map›Paper›PMID 29052616›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2018

Pregenual Anterior Cingulate Dysfunction Associated with Depression in OCD: An Integrated Multimodal fMRI/

Reza Tadayonnejad, Rangaprakash Deshpande, Olusola Ajilore, Teena Moody, Francesca Morfini, Ronald Ly, Joseph O'Neill, Jamie D Feusner

Abstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Reza TadayonnejadDivision of Adult Psychiatry, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.ORCID 0000-0002-4665-6721
Rangaprakash DeshpandeDivision of Adult Psychiatry, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.
Olusola AjiloreDepartment of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA.ORCID 0000-0003-0737-0437
Teena MoodyDivision of Adult Psychiatry, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.
Francesca MorfiniDivision of Adult Psychiatry, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.
Ronald LyDivision of Adult Psychiatry, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.
Joseph O'NeillDivision of Child and Adolescent Psychiatry, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.
Jamie D FeusnerDivision of Adult Psychiatry, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.

Funding

Anxiety and reward interaction and prediction of outcomes in anorexia nervosaR01MH105662 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEUSNER, JAMIE · 2015 to 2019
$2.3M
Cognitive-Behavioral Therapy and Glutamate in Cingulate Gyrus in OCDR01MH085900 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEUSNER, JAMIE, O'NEILL, JOSEPH · 2011 to 2014
$1.8M
Understanding the dynamics of visual processing abnormalities in body dysmorphic disorderR21MH110865 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEUSNER, JAMIE · 2017 to 2018
$454k
NIMH NIH HHS R01 MH085900NIMH NIH HHS R01 MH105662NIMH NIH HHS R21 MH110865
6 · The paper itself

Abstract

Depression is a commonly occurring symptom in obsessive-compulsive disorder (OCD), and is associated with worse functional impairment, poorer quality of life, and poorer treatment response. Understanding the underlying neurochemical and connectivity-based brain mechanisms of this important symptom domain in OCD is necessary for development of novel, more globally effective treatments. To investigate biopsychological mechanisms of comorbid depression in OCD, we examined effective connectivity and neurochemical signatures in the pregenual anterior cingulate cortex (pACC), a structure known to be involved in both OCD and depression. Resting-state functional magnetic resonance imaging (fMRI) and

Indexed as

AdultCase-Control StudiesDepressionFemaleFunctional NeuroimagingGlutamic AcidGyrus CinguliHumansMagnetic Resonance ImagingMaleNeural PathwaysObsessive-Compulsive DisorderProton Magnetic Resonance SpectroscopyYoung AdultGlutamic Acid

Identifiers

PMID29052616
PMCPMC5854805

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.