ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2018
Effects of Alcohol Abuse on Proliferating Cells, Stem/Progenitor Cells, and Immature Neurons in the Adult Human Hippocampus.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Hippocampal neurogenesis in adult primates: a systematic review.Molecular psychiatry · 2025Pooled it
- Insomnia-Driven Hippocampal Atrophy: Evidence From Bidirectional Mendelian Randomization.Health science reports · 2026Article
- Mechanisms of Alcohol Interference with Hippocampal Neurogenesis and its Repair Strategies.Molecular neurobiology · 2025Review
- Human adult hippocampal neurogenesis is shaped by neuropsychiatric disorders, demographics, and lifestyle-related factors.Cell stem cell · 2025Article
- White matter neural substrates in alcohol dependence with genetic risk and their role in pathological reward process.Scientific reports · 2025Article
- Neuroprotective effects of Simvastatin against alcohol-induced oxidative stress and neurodegeneration in the Hippocampus of adolescent mice.Metabolic brain disease · 2025Article
- The Causal Relationship Between Asthma and Hippocampal Volume: A Study Based on Bidirectional Mendelian Randomization Analysis.Brain and behavior · 2025Article
- Human adult hippocampal neurogenesis in health and disease.Aging brain · 2025Article
- Extent and activity of adult hippocampal neurogenesis.Frontiers in neuroscience · 2025Review
- The impact of adult neurogenesis on affective functions: of mice and men.Molecular psychiatry · 2024Review
- Progenitor Cells Play a Role in Reinstatement of Ethanol Seeking in Adult Male and Female Ethanol Dependent Rats.International journal of molecular sciences · 2023Article
- Detrimental Effects of Alcohol-Induced Inflammation on Brain Health: From Neurogenesis to Neurodegeneration.Cellular and molecular neurobiology · 2023Review
- Article
- The gene expression patterns as surrogate indices of pH in the brain.Frontiers in psychiatry · 2023Article
- Article
- Functional Activation of Newborn Neurons Following Alcohol-Induced Reactive Neurogenesis.Brain sciences · 2021Article
- Evidences for Adult Hippocampal Neurogenesis in Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Hippocampal regenerative medicine: neurogenic implications for addiction and mental disorders.Experimental & molecular medicine · 2021Review
- Reactive, Adult Neurogenesis From Increased Neural Progenitor Cell Proliferation Following Alcohol Dependence in Female Rats.Frontiers in neuroscience · 2021Article
- Recovery of Hippocampal-Dependent Learning Despite Blunting Reactive Adult Neurogenesis After Alcohol Dependence.Brain plasticity (Amsterdam, Netherlands) · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
In animal studies, impaired adult hippocampal neurogenesis is associated with behavioral pathologies including addiction to alcohol. We hypothesize that alcohol abuse may have a detrimental effect on the neurogenic pool of the dentate gyrus in the human hippocampus. In this study we investigate whether alcohol abuse affects the number of proliferating cells, stem/progenitor cells, and immature neurons in samples from postmortem human hippocampus. The specimens were isolated from deceased donors with an on-going alcohol abuse, and from controls with no alcohol overconsumption. Mid-hippocampal sections were immunostained for Ki67, a marker for cell proliferation, Sox2, a stem/progenitor cell marker, and DCX, a marker for immature neurons. Immunoreactivity was counted in alcoholic subjects and compared with controls. Counting was performed in the three layers of dentate gyrus: the subgranular zone, the granular cell layer, and the molecular layer. Our data showed reduced numbers of all three markers in the dentate gyrus in subjects with an on-going alcohol abuse. This reduction was most prominent in the subgranular zone, and uniformly distributed across the distances from the granular cell layer. Furthermore, alcohol abusers showed a more pronounced reduction of Sox2-IR cells than DCX-IR cells, suggesting that alcohol primarily causes a depletion of the stem/progenitor cell pool and that immature neurons are secondarily affected. These results are in agreement with observations of impaired adult hippocampal neurogenesis in animal studies and lend further support for the association between hippocampal dysfunction and alcohol abuse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.