SynthesisEndocrine2018
Effectiveness of myoinositol for polycystic ovary syndrome: a systematic review and meta-analysis.
Synthesis in Endocrine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 6 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Effects of inositol in women with polycystic ovary syndrome: an umbrella review of meta-analyses from randomized controlled trials.Frontiers in endocrinology · 2026Pooled it
- Pooled it
- Efficacy of dietary supplements as an adjunctive therapy for polycystic ovary syndrome: an umbrella meta-analysis.Frontiers in nutrition · 2025Pooled it
- Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials.Reproductive biology and endocrinology : RB&E · 2023Pooled it
- Efficacy of Myo-inositol on Anthropometric, Metabolic, and Endocrine Outcomes in PCOS Patients: a Meta-analysis of Randomized Controlled Trial.Reproductive sciences (Thousand Oaks, Calif.) · 2022Pooled it
- Improvement of Insulin Sensitivity Increases Pregnancy Rate in Infertile PCOS Women: A Systemic Review.Frontiers in endocrinology · 2021Pooled it
- Diagnosis and Treatment of Adolescent Polycystic Ovary syndrome:A Review.International journal of women's health · 2025Review
- The Cardiometabolic Risk in Women with Polycystic Ovarian Syndrome (PCOS): From Pathophysiology to Diagnosis and Treatment.Medicina (Kaunas, Lithuania) · 2024Review
- The Effectiveness of Myo-Inositol in Women With Polycystic Ovary Syndrome: A Prospective Clinical Study.Cureus · 2024Article
- A Literature Review and a Proposed Classification of the Relationships between Ovulatory Infertility and Lifestyle Factors Based on the Three Groups of Ovulation Disorders Classified by WHO.Journal of clinical medicine · 2023Review
- Neurobiology and Applications of Inositol in Psychiatry: A Narrative Review.Current issues in molecular biology · 2023Review
- Female infertility in the era of obesity: The clash of two pandemics or inevitable consequence?Clinical endocrinology · 2023Review
- Prospective Risk of Type 2 Diabetes in Normal Weight Women with Polycystic Ovary Syndrome.Biomedicines · 2022Review
- Polycystic ovary syndrome and type 2 diabetes mellitus: A state-of-the-art review.World journal of diabetes · 2022Review
- Maintaining Effective Beta Cell Function in the Face of Metabolic Syndrome-Associated Glucolipotoxicity-Nutraceutical Options.Healthcare (Basel, Switzerland) · 2021Review
- Inositols in PCOS.Molecules (Basel, Switzerland) · 2020Review
- Safety and efficacy of supplements in pregnancy.Nutrition reviews · 2020Review
- Altered Ovarian Inositol Ratios May Account for Pathological Steroidogenesis in PCOS.International journal of molecular sciences · 2020Review
- From Prediabetes to Type 2 Diabetes Mellitus in Women with Polycystic Ovary Syndrome: Lifestyle and Pharmacological Management.International journal of endocrinology · 2020Review
- Inositol Treatment for PCOS Should Be Science-Based and Not Arbitrary.International journal of endocrinology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo assess the effectiveness and safety of myoinositol for patients with PCOS.
methodsIn this meta-analysis, data from randomized controlled trials are obtained to assess the effects of myoinositol vs. placebo or western medicine in women with PCOS. The study's registration number is CRD42017064563. The primary outcomes included total testosterone, estradiol (E2) and the homeostatic model assessment (HOMA) of insulin resistance.
resultTen trials involving 573 patients were included. The meta-analysis results show that: compared with the control group, myoinositol may improve HOMA index (WMD -0.65; 95% CI -1.02, -0.28; P = 0. 0005) and increase the E2 level (WMD 16.16; 95% CI 2.01, 30.31; P = 0. 03); while there is no enough strong evidence that the myoinositol has an effect on the total testosterone level (WMD -16.11; 95% CI -46.08, 13.86; P = 0. 29).
conclusionBased on current evidence, myoinositol may be recommended for the treatment of PCOS with insulin resistance, as well as for improving symptoms caused by decreased estrogen in PCOS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.