Evidence map›Paper›PMID 29052045›Full record

ReviewHeart failure reviews2018

Hypothalamic dysfunction in heart failure: pathogenetic mechanisms and therapeutic implications.

Antonios Rigas, Dimitrios Farmakis, Georgios Papingiotis, Georgios Bakosis, John Parissis

Abstract readReview
PubMed Publisher
In one paragraph

Review in Heart failure reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Hypothalamic Inflammation at a Crossroad of Somatic Diseases.Cellular and molecular neurobiology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Antonios RigasHeart Failure Unit, Department of Cardiology, Athens University Hospital "Attikon", National and Kapodistrian University of Athens, Athens, Greece.
Dimitrios FarmakisHeart Failure Unit, Department of Cardiology, Athens University Hospital "Attikon", National and Kapodistrian University of Athens, Athens, Greece. dimitrios_farmakis@yahoo.com.
Georgios PapingiotisHeart Failure Unit, Department of Cardiology, Athens University Hospital "Attikon", National and Kapodistrian University of Athens, Athens, Greece.
Georgios BakosisHeart Failure Unit, Department of Cardiology, Athens University Hospital "Attikon", National and Kapodistrian University of Athens, Athens, Greece.
John ParissisHeart Failure Unit, Department of Cardiology, Athens University Hospital "Attikon", National and Kapodistrian University of Athens, Athens, Greece.
National and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurohumoral activation is an important feature of heart failure. Recent advances in molecular biology and imaging techniques permitted a better understanding of the central role that hypothalamus plays in the modulation of dysfunctional mechanisms, as well as the occurrence of comorbidities, such as depression, in heart failure patients. This review summarizes the commonly reported neural reflexes and molecular signaling pathways at the level of the hypothalamus along with the dysfunctional mechanisms within the paraventricular nucleus and other areas of the hypothalamus in heart failure and describes some relevant therapeutic implications.

Indexed as

AnimalsHeart FailureHumansNeurosecretory SystemsParaventricular Hypothalamic NucleusSympathetic Nervous SystemDepressionHeart failureHypothalamusHypothalamus-pituitary axisInflammationNeurohormonal activation

Identifiers

PMID29052045
OpenAlexW2765931195

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.