Evidence map›Paper›PMID 29052034›Full record

Observational studyAging clinical and experimental research2018

High-molecular-weight adiponectin levels in healthy, community-dwelling, elderly Japanese volunteers: a 5-year prospective observational study.

Hiromasa Otsuka, Mitsuru Yanai, Hiroki Kobayashi, Akira Haketa, Motohiko Hara, Kaoru Sugama, Kimitoshi Kato, Masayoshi Soma

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Aging clinical and experimental research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Observational
  2. Review
  3. Obesity-induced cognitive impairment in older adults: a microvascular perspective.American journal of physiology. Heart and circulatory physiology · 2021
    Article
  4. Observational
  5. Article
  6. Observational
  7. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hiromasa OtsukaDivision of General Medicine, Department of Internal Medicine, Nihon University School of Medicine, Oyaguchikamimachi 30-1, Itabashi-ku, Tokyo, Japan.
Mitsuru YanaiDivision of General Medicine, Department of Internal Medicine, Nihon University School of Medicine, Oyaguchikamimachi 30-1, Itabashi-ku, Tokyo, Japan. yanai.mitsuru@nihon-u.ac.jp.ORCID http://orcid.org/0000-0002-6864-5943
Hiroki KobayashiDivision of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
Akira HaketaDivision of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
Motohiko HaraDepartment of Nursing, School of Health and Social Services, Saitama Prefectural University, Tokyo, Japan.
Kaoru SugamaDivision of Cell Regeneration and Transplantation, Department of Functional Morphology, Nihon University School of Medicine, Tokyo, Japan.
Kimitoshi KatoDivision of General Medicine, Department of Internal Medicine, Nihon University School of Medicine, Oyaguchikamimachi 30-1, Itabashi-ku, Tokyo, Japan.
Masayoshi SomaDivision of General Medicine, Department of Internal Medicine, Nihon University School of Medicine, Oyaguchikamimachi 30-1, Itabashi-ku, Tokyo, Japan.
Nihon University · JPSaitama Prefectural University · JP

Funding

The Strategic Research Base Development Program for Private Universities, subsidized by the Ministry of Education, Culture, Sports, Science & Technology (MEXT) in Japan (2011) S1101018
6 · The paper itself

Abstract

backgroundSerum adiponectin levels are associated with frailty and cardiovascular diseases. Longitudinal changes in adiponectin levels might enhance our understanding of age-related conditions and diseases.

aimsThis prospective observational study aimed to: (1) elucidate age-related changes in high-molecular-weight (HMW) adiponectin levels; and (2) identify variables predictive of elevated HMW adiponectin levels and the association with well-known adiponectin single-nucleotide polymorphisms (SNPs) in healthy, elderly Japanese participants.

methodsHealthy elderly volunteers (n = 196; 55 men and 141 women; median age 72.0 years; range 69.0-75.0 years) underwent anthropometric and physical function measurements, as well as laboratory tests at baseline and the 5-year follow-up.

resultsHMW adiponectin levels were significantly higher in women than in men (8.4, 5.3-11.9 vs. 5.7, 3.1-9.0 μg/mL; p < 0.001) at baseline and decreased significantly at follow-up in women (7.7, 4.8-11.2 μg/mL; p < 0.001), but not in men. In the multiple regression analysis, high-density lipoprotein cholesterol levels and body weight were independent predictors of HMW adiponectin levels. The rate of change in HMW adiponectin levels was inversely correlated with the rates of change in body weight, body mass index, and knee leg extension strengths, and positively correlated with rates of change in high-density lipoprotein cholesterol and one-leg standing time. There were no significant differences in HMW adiponectin levels among SNPs. DISCUSSION: Decreasing HMW adiponectin levels might lead to an increased risk of cardiovascular diseases in elderly women.

conclusionHMW adiponectin levels significantly decreased over a 5-year period in community-dwelling elderly Japanese women.

Indexed as

AdiponectinAgedBody Mass IndexBody WeightCardiovascular DiseasesCholesterol, HDLFemaleHumansIndependent LivingJapanMaleMuscle StrengthPolymorphism, Single NucleotideProspective StudiesRegression AnalysisSex DistributionAdiponectinCholesterol, HDLBody weightHigh-molecular-weight adiponectinMuscle strengthProspective study

Identifiers

PMID29052034
PMCPMC6008340
OpenAlexW2766577405

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.