ArticlePsychopharmacology2018
Effect of repeated abstinence on chronic ethanol self-administration in the rhesus monkey.
Article in Psychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Pre-existing DNA methylation signatures in the prefrontal cortex of alcohol-naïve nonhuman primates define neural vulnerability for future risky ethanol consumption.Neurobiology of disease · 2025Article
- Synchrony between midbrain gene transcription and dopamine terminal regulation is modulated by chronic alcohol drinking.Nature communications · 2025Article
- Article
- Impact of heavy alcohol consumption on cortical bone mechanical properties in male rhesus macaques.Bone · 2024Article
- Effects of repeated alcohol abstinence on within-subject prefrontal cortical gene expression in rhesus macaques.Advances in drug and alcohol research · 2024Article
- Integrated single cell analysis shows chronic alcohol drinking disrupts monocyte differentiation in the bone marrow.Stem cell reports · 2023Article
- GDNF gene therapy for alcohol use disorder in male non-human primates.Nature medicine · 2023Article
- Integrated single cell analysis shows chronic alcohol drinking disrupts monocyte differentiation in the bone marrow niche.bioRxiv : the preprint server for biology · 2023Article
- Ketamine plus Alcohol: What We Know and What We Can Expect about This.International journal of molecular sciences · 2022Review
- Replicability in measures of attentional set-shifting task performance predicting chronic heavy drinking in rhesus monkeys.Alcohol (Fayetteville, N.Y.) · 2021Article
- Long-term alcohol consumption alters dorsal striatal dopamine release and regulation by D2 dopamine receptors in rhesus macaques.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Mifepristone Decreases Chronic Voluntary Ethanol Consumption in Rhesus Macaques.The Journal of pharmacology and experimental therapeutics · 2020Article
- Daily Ethanol Drinking Followed by an Abstinence Period Impairs Bone Marrow Niche and Mitochondrial Function of Hematopoietic Stem/Progenitor Cells in Rhesus Macaques.Alcoholism, clinical and experimental research · 2020Article
- Discriminative Stimulus Effects and Metabolism of Ethanol in Rhesus Monkeys.Alcoholism, clinical and experimental research · 2019Article
- Dose-dependent effects of chronic alcohol drinking on peripheral immune responses.Scientific reports · 2019Article
- Chronic heavy drinking drives distinct transcriptional and epigenetic changes in splenic macrophages.EBioMedicine · 2019Article
- Modulation of Gpr39, a G-protein coupled receptor associated with alcohol use in non-human primates, curbs ethanol intake in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Low cognitive flexibility as a risk for heavy alcohol drinking in non-human primates.Alcohol (Fayetteville, N.Y.) · 2019Article
- Cross-Species Co-analysis of Prefrontal Cortex Chronic Ethanol Transcriptome Responses in Mice and Monkeys.Frontiers in molecular neuroscience · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleAbstinence-based approaches to treating alcohol use disorder (AUD) are highly prevalent, but abstinence from chronic drinking may exacerbate subsequent levels of alcohol intake in relapse.
objectiveUse a non-human primate model that encompasses a range of chronic voluntary ethanol drinking to isolate biological responses to repeated cycles of imposed abstinence as a function of baseline voluntary alcohol drinking levels.
methodsOver a 26-month protocol, young adult male rhesus macaques were first induced to drink alcohol and then given continuous access to 4% (w/v) ethanol (n = 8) or water (n = 4) for approximately 14 months, followed by three 28- to 35-day abstinence phases, with 3 months of ethanol access in between. Ethanol intake and blood ethanol concentration (BEC) were the primary dependent variables. Observational signs of physical dependence and circulating ACTH and cortisol were monitored.
resultsPrior to abstinence, stable, categorical, individual differences in voluntary ethanol intake under chronic access conditions were found. Following abstinence, categorical "non-heavy" drinking subjects increased drinking transiently (increased between 0.7 and 1.4 g/kg/day in first month after abstinence) but returned to baseline after 3 months. Categorical "heavy" drinkers, however, maintained drinking 1.0-2.6 g/kg above baseline for over 3 months following abstinence. Signs of physical dependence were rare, although huddling and social withdrawal increased in ethanol and control subjects. The most prominent effect on hormonal measures was heightened cortisol during abstinence that increased to a greater extent in ethanol subjects.
conclusionInvoluntary abstinence increases drinking in the absence of overt physical withdrawal symptoms, and heavy drinkers are more robustly affected compared to non-heavy drinkers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.