ArticleNature human behaviour2017
Hidden heritability due to heterogeneity across seven populations.
Article in Nature human behaviour, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 6 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
76 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Overcoming attenuation bias in regressions using polygenic indices.Nature communications · 2023Pooled it
- Pooled it
- Robust genetic nurture effects on education: A systematic review and meta-analysis based on 38,654 families across 8 cohorts.American journal of human genetics · 2021Pooled it
- Heritability of blood pressure traits in diverse populations: a systematic review and meta-analysis.Journal of human hypertension · 2019Pooled it
- A scientometric review of genome-wide association studies.Communications biology · 2019Pooled it
- Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.Nature genetics · 2018Pooled it
- Genetics of major depressive disorder in a homogeneous population with uniform phenotyping.Molecular psychiatry · 2026Article
- The Sociogenomics of Social Stratification and General Theories of Inequality.The British journal of sociology · 2026Article
- Early-career-researcher-led best practices for social science and behavioural genetics.Nature human behaviour · 2026Article
- Analysis of trait differences and identification of superior early growth combinations in interspecific hybrid progenies of Gleditsia sinensis.BMC plant biology · 2026Article
- Leveraging polygenic risk scores to infer causal directions in genotype-by-environment interactions between complex traits.Human genetics · 2026Article
- Cross-Ancestry Polygenic Prediction: Comparing Methods and Assessing Transferability Across Traits.Genetic epidemiology · 2026Article
- Personality Genomics.Annual review of psychology · 2026Review
- Genetics of Major Depressive Disorder in a Homogeneous Population with Uniform Phenotyping.Research square · 2025Article
- Deciphering the influence of socioeconomic status on brain structure: insights from Mendelian randomization.Molecular psychiatry · 2025Article
- The Role of SLC39A8.p.(Ala391Thr) in Schizophrenia Symptom Severity and Cognitive Ability: Cross-Sectional Studies of Schizophrenia and the General UK Population.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2025Article
- Indirect genetic effects among neighbors promote cooperation and accelerate adaptation in a small-scale human society.Science advances · 2025Article
- Polygenic Associations With Educational Attainment in East Versus West Germany: Differences Emerge After Reunification.Psychological science · 2025Article
- Socio-economic status is a social construct with heritable components and genetic consequences.Nature human behaviour · 2025Review
- Associations between common genetic variants and income provide insights about the socio-economic health gradient.Nature human behaviour · 2025Article
16 more citing papers are in PubMed but not listed here.
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Authors and funding
19 authors.
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Abstract
Meta-analyses of genome-wide association studies (GWAS), which dominate genetic discovery are based on data from diverse historical time periods and populations. Genetic scores derived from GWAS explain only a fraction of the heritability estimates obtained from whole-genome studies on single populations, known as the 'hidden heritability' puzzle. Using seven sampling populations (N=35,062), we test whether hidden heritability is attributed to heterogeneity across sampling populations and time, showing that estimates are substantially smaller from across compared to within populations. We show that the hidden heritability varies substantially: from zero (height), to 20% for BMI, 37% for education, 40% for age at first birth and up to 75% for number of children. Simulations demonstrate that our results more likely reflect heterogeneity in phenotypic measurement or gene-environment interaction than genetic heterogeneity. These findings have substantial implications for genetic discovery, suggesting that large homogenous datasets are required for behavioural phenotypes and that gene-environment interaction may be a central challenge for genetic discovery.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.