ArticleChemical science2012
Synthetic lectin arrays for the detection and discrimination of cancer associated glycans and cell lines.
Article in Chemical science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 44 citations in OpenAlex.
- Characterization of sialylation-related long noncoding RNAs to develop a novel signature for predicting prognosis, immune landscape, and chemotherapy response in colorectal cancer.Frontiers in immunology · 2022Article
- Discrimination and Quantitation of Biologically Relevant Carboxylate Anions Using A [Dye•PAMAM] Complex.Sensors (Basel, Switzerland) · 2021Article
- Glycans and Glycan-Binding Proteins as Regulators and Potential Targets in Leukocyte Recruitment.Frontiers in cell and developmental biology · 2021Review
- The mechanisms of boronate ester formation and fluorescent turn-on in ortho-aminomethylphenylboronic acids.Nature chemistry · 2019Review
- Sequence-based predictive modeling to identify cancerlectins.Oncotarget · 2017Article
- Fluorogenic sensor platform for the histone code using receptors from dynamic combinatorial libraries.Chemical science · 2017Article
- Eradicating mass spectrometric glycan rearrangement by utilizing free radicals.Chemical science · 2016Article
- Serum N-glycan analysis in breast cancer patients--Relation to tumour biology and clinical outcome.Molecular oncology · 2016Article
- A polyion complex sensor array for markerless and noninvasive identification of differentiated mesenchymal stem cells from human adipose tissue.Chemical science · 2015Article
- A Multichannel Biosensor for Rapid Determination of Cell Surface Glycomic Signatures.ACS central science · 2015Article
- In situ recognition of cell-surface glycans and targeted imaging of cancer cells.Scientific reports · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Aberrant glycosylation is a hallmark of various disease states, including cancer, and effective detection and discrimination between healthy and diseased cells is an important challenge for the diagnosis and treatment of many diseases. Here, we describe the use of boronic acid functionalized synthetic lectins (SLs) in an array format for the differentiation of structurally similar cancer associated glycans and cancer cell lines; discrimination is based on subtle variations in glycosylation patterns. We further demonstrate the utility of our SLs in recognizing glycoproteins with up to 50-fold selectivity, even in 95% human serum. Given their robust and selective nature, these SLs were able to effectively distinguish (a) five structurally similar glycans with 94% accuracy; (b) seven normal, cancerous and metastatic colon cancer cell lines, including three isogenic cell lines, with 92% accuracy; and (c) these same seven cell lines using a guided statistical analysis to improve our analysis to 97% accuracy. In total, these data suggest that an SL-based array will be useful for the diagnosis of cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.