ArticleObstetric medicine2017
Prediction of adverse pregnancy outcomes by extreme values of first trimester screening markers.
Article in Obstetric medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 18 citations in OpenAlex.
- The effect of fetal gender on the biochemical markers of the first-trimester screening.Saudi medical journal · 2022Article
- Recurrent preterm birth risk assessment for two delivery subtypes: A multivariable analysis.Journal of the American Medical Informatics Association : JAMIA · 2022Article
- Low First Trimester Pregnancy-Associated Plasma Protein-A Levels Are Not Associated with an Increased Risk of Intrapartum Fetal Compromise or Adverse Neonatal Outcomes: A Retrospective Cohort Study.Journal of clinical medicine · 2020Article
- Assessment of β-human-derived chorionic gonadotrophic hormone (βhCG) and pregnancy-associated plasma protein A (PAPP-A) levels as predictive factors of preeclampsia in the first trimester among Iranian women: a cohort study.BMC pregnancy and childbirth · 2019Article
- Relationship between False Positive Screening Results of Down Syndrome and Adverse Pregnancy Outcomes.Iranian journal of nursing and midwifery researchArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo determine the association between extreme values of first trimester markers and adverse pregnancy outcomes.
methodsA retrospective cohort study of 916 women who underwent first-trimester combined screening during 2015 was performed. Extreme values of NT, pregnancy-associated plasma protein-A (PAPP-A) and free β-hCG, and their association with adverse pregnancy outcomes were analyzed.
resultsLow PAPP-A (<10th percentile) was associated with an increased risk for preeclampsia (adjusted odds ratio (AOR) 4.13), fetal growth restriction (AOR 3.94) and abruptio placentae (AOR 52.63). Abnormally low or high free β-hCG, high PAPP-A or increased NT was not associated with an increased risk for adverse outcomes. DISCUSSION: PAPP-A <10th percentile could be associated with an increased risk for adverse outcomes. However, the majority of patients with these events do not have abnormal PAPP-A and few patients with PAPP-A <10th percentile will have an adverse outcome.
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