Observational studyScientific reports2017
Stromal striae: a new insight into corneal physiology and mechanics.
Observational study in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 53 citations in OpenAlex.
- Role of Neural Crest Cells in Establishing Corneal Transparency During Embryonic Development in Mice.Journal of cellular physiology · 2026Article
- CorvisThe British journal of ophthalmology · 2026Article
- The Impact of Dry Eye Disease on Corneal Biomechanics Analyzed with Corneal Visualization Scheimpflug Technology.Biomedicines · 2025Article
- Transmission interference microscopy of anterior human eye.Nature communications · 2025Article
- Harnessing forward multiple scattering for optical imaging deep inside an opaque medium.Nature communications · 2024Article
- Comparing the clinical applicability of wavefront phase imaging in keratoconus versus normal eyes.Scientific reports · 2024Article
- Systemic and Ocular Associations of Keratoconus.Expert review of ophthalmology · 2024Article
- Characteristics of corneal aberration in patients with bilateral keratoconus and unilateral corneal Vogt's striae.International journal of ophthalmology · 2024Article
- Unveiling the lamellar structure of the human cornea over its full thickness using polarization-resolved SHG microscopy.Light, science & applications · 2023Article
- Corneal densitometry in bilateral keratoconus patients with unilateral corneal Vogt's striae: a contralateral eye study.International ophthalmology · 2023Article
- Comprehensive Assessment of Corvis ST Biomechanical Indices in Normal and Keratoconus Corneas with Reference to Corneal Enantiomorphism.Journal of clinical medicine · 2023Article
- Biomechanics of keratoconus: Two numerical studies.PloS one · 2023Article
- The Influence of Eyelid Position and Environmental Conditions on the Corneal Changes in Early Postmortem Interval: A Prospective, Multicentric OCT Study.Diagnostics (Basel, Switzerland) · 2022Article
- Quantitative structural imaging of keratoconic corneas using polarization-resolved SHG microscopy.Biomedical optics express · 2021Article
- Postmortem Ocular Findings in the Optical Coherence Tomography Era: A Proof of Concept Study Based on Six Forensic Cases.Diagnostics (Basel, Switzerland) · 2021Article
- Risk Factors for Development of Keratoconus: A Matched Pair Case-Control Study.Clinical ophthalmology (Auckland, N.Z.) · 2021Article
- The architecture of corneal stromal striae on optical coherence tomography and histology in an animal model and in humans.Scientific reports · 2020Article
- Corneal stromal stem cells restore transparency after NStem cells translational medicine · 2020Article
- Real-time non-contact cellular imaging and angiography of human cornea and limbus with common-path full-field/SD OCT.Nature communications · 2020Article
- Fourier-Domain OCT Imaging of the Ocular Surface and Tear Film Dynamics: A Review of the State of the Art and an Integrative Model of the Tear Behavior During the Inter-Blink Period and Visual Fixation.Journal of clinical medicine · 2020Review
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We uncover the significance of a previously unappreciated structural feature in corneal stroma, important to its biomechanics. Vogt striae are a known clinical indicator of keratoconus, and consist of dark, vertical lines crossing the corneal depth. However we detected stromal striae in most corneas, not only keratoconus. We observed striae with multiple imaging modalities in 82% of 118 human corneas, with pathology-specific differences. Striae generally depart from anchor points at Descemet's membrane in the posterior stroma obliquely in a V-shape, whereas in keratoconus, striae depart vertically from posterior toward anterior stroma. Optical coherence tomography shear wave elastography showed discontinuity of rigidity, and second harmonic generation and scanning electron microscopies showed undulation of lamellae at striae locations. Striae visibility decreased beyond physiological pressure and increased beyond physiological hydration. Immunohistology revealed striae to predominantly contain collagen VI, lumican and keratocan. The role of these regions of collagen VI linking sets of lamellae may be to absorb increases in intraocular pressure and external shocks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.