Evidence map›Paper›PMID 29051506›Full record

ArticleScientific reports2017

An integrated EEG and eye-tracking approach for the study of responding and initiating joint attention in Autism Spectrum Disorders.

Lucia Billeci, Antonio Narzisi, Alessandro Tonacci, Beatrice Sbriscia-Fioretti, Luca Serasini, Francesca Fulceri, Fabio Apicella, Federico Sicca, Sara Calderoni, Filippo Muratori

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05271955 (Medico-economic Evaluation of the Care by Serious Games in Outpatient Units and at Home for Children With Autism Spectrum Disorders), which is not on this map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05271955 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Medico-economic Evaluation of the Care by Serious Games in Outpatient Units and at Home for Children With Autism Spectrum Disorders

TypeinterventionalSponsorAssistance Publique - Hôpitaux de ParisRan2022 to 2024Enrolled150ConditionsAutism Spectrum DisorderArms"e-GOLIAH", Usual care
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.

  1. Pooled it
  2. Eye Tracking as a Treatment Monitoring Tool for Autism: A Multilevel Meta-Analysis.Autism research : official journal of the International Society for Autism Research · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Lucia BilleciInstitute of Clinical Physiology, National Research Council of Italy, Via Moruzzi 1, 56124, Pisa, Italy. lucia.billeci@ifc.cnr.it.
Antonio NarzisiIRCCS Stella Maris Foundation, Viale del Tirreno 331, 56018, Calambrone, (PI), Italy.
Alessandro TonacciInstitute of Clinical Physiology, National Research Council of Italy, Via Moruzzi 1, 56124, Pisa, Italy.
Beatrice Sbriscia-FiorettiAzienda Ospedaliero-Universitaria di Parma, Strada Abbeveratoia, 2, 43100, Parma, Italy.
Luca SerasiniInstitute of Clinical Physiology, National Research Council of Italy, Via Moruzzi 1, 56124, Pisa, Italy.
Francesca FulceriIRCCS Stella Maris Foundation, Viale del Tirreno 331, 56018, Calambrone, (PI), Italy.
Fabio ApicellaIRCCS Stella Maris Foundation, Viale del Tirreno 331, 56018, Calambrone, (PI), Italy.
Federico SiccaIRCCS Stella Maris Foundation, Viale del Tirreno 331, 56018, Calambrone, (PI), Italy.
Sara CalderoniIRCCS Stella Maris Foundation, Viale del Tirreno 331, 56018, Calambrone, (PI), Italy.
Filippo MuratoriIRCCS Stella Maris Foundation, Viale del Tirreno 331, 56018, Calambrone, (PI), Italy.
Fondazione Stella Maris · ITIstituto di Fisiologia Clinica · ITOspedale di Parma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism Spectrum Disorders (ASD) are characterised by impairment in joint attention (JA), which has two components: the response to JA and the initiation of JA. Literature suggests a correlation between JA and neural circuitries, although this link is still largely unexplored in ASD. In this pilot study, we aimed at investigating the neural correlates of responding and initiating JA in high-functioning children with ASD and evaluating the changes in brain function and visual pattern after six months of rehabilitative treatment using an integrated EEG/eye-tracking system. Our results showed that initiating and responding JA subtend both overlapping (i.e. frontal and temporal) and specialized (i.e. parietal for responding JA and occipital for initiating JA) neural circuitries. In addition, in a subgroup of subjects, we observed trends of changes in both brain activity and connectivity after rehabilitative treatment in both the two tasks, which were correlated with modifications in gaze measures. These preliminary results, if confirmed in a larger sample, suggest the feasibility of using the proposed multimodal approach to characterise JA-related brain circuitries and visual pattern in ASD individuals and to monitor longitudinal changes in response to rehabilitative intervention.

Indexed as

AttentionAutism Spectrum DisorderBrainChildElectroencephalographyEyeHumansMalePhotic StimulationPilot Projects

Identifiers

PMID29051506
PMCPMC5648821
OpenAlexW2762482812

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.