Evidence map›Paper›PMID 29051497›Full record

ArticleNature communications2017

Achieving high-efficiency emission depletion nanoscopy by employing cross relaxation in upconversion nanoparticles.

Qiuqiang Zhan, Haichun Liu, Baoju Wang, Qiusheng Wu, Rui Pu, Chao Zhou, Bingru Huang, Xingyun Peng, Hans Ågren, Sailing He

Abstract read
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed.

  1. Article
  2. Article
  3. Upconversion Luminescence of NaYFNanomaterials (Basel, Switzerland) · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Modulating parallel photon avalanche in HoLight, science & applications · 2025
    Article
  8. Article
  9. Inhibiting concentration quenching in YbNature communications · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qiuqiang ZhanCentre for Optical and Electromagnetic Research, South China Academy of Advanced Optoelectronics, South China Normal University, 510006, Guangzhou, P.R. China. zhanqiuqiang@m.scnu.edu.cn.ORCID http://orcid.org/0000-0002-5886-3795
Haichun LiuDivision of Theoretical Chemistry and Biology, Royal Institute of Technology, S-10691, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-1780-7746
Baoju WangCentre for Optical and Electromagnetic Research, South China Academy of Advanced Optoelectronics, South China Normal University, 510006, Guangzhou, P.R. China.
Qiusheng WuCentre for Optical and Electromagnetic Research, South China Academy of Advanced Optoelectronics, South China Normal University, 510006, Guangzhou, P.R. China.
Rui PuCentre for Optical and Electromagnetic Research, South China Academy of Advanced Optoelectronics, South China Normal University, 510006, Guangzhou, P.R. China.
Chao ZhouCentre for Optical and Electromagnetic Research, South China Academy of Advanced Optoelectronics, South China Normal University, 510006, Guangzhou, P.R. China.
Bingru HuangCentre for Optical and Electromagnetic Research, South China Academy of Advanced Optoelectronics, South China Normal University, 510006, Guangzhou, P.R. China.
Xingyun PengCentre for Optical and Electromagnetic Research, South China Academy of Advanced Optoelectronics, South China Normal University, 510006, Guangzhou, P.R. China.
Hans ÅgrenDivision of Theoretical Chemistry and Biology, Royal Institute of Technology, S-10691, Stockholm, Sweden.
Sailing HeCentre for Optical and Electromagnetic Research, South China Academy of Advanced Optoelectronics, South China Normal University, 510006, Guangzhou, P.R. China. sailing@kth.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stimulated emission depletion microscopy provides a powerful sub-diffraction imaging modality for life science studies. Conventionally, stimulated emission depletion requires a relatively high light intensity to obtain an adequate depletion efficiency through only light-matter interaction. Here we show efficient emission depletion for a class of lanthanide-doped upconversion nanoparticles with the assistance of interionic cross relaxation, which significantly lowers the laser intensity requirements of optical depletion. We demonstrate two-color super-resolution imaging using upconversion nanoparticles (resolution ~ 66 nm) with a single pair of excitation/depletion beams. In addition, we show super-resolution imaging of immunostained cytoskeleton structures of fixed cells (resolution ~ 82 nm) using upconversion nanoparticles. These achievements provide a new perspective for the development of photoswitchable luminescent probes and will broaden the applications of lanthanide-doped nanoparticles for sub-diffraction microscopic imaging.

Indexed as

NanoparticlesColorCytoskeletonHeLa CellsHumansLuminescenceMicroscopyMicroscopy, Electron, TransmissionMicroscopy, FluorescenceMolecular ProbesThuliumMolecular ProbesThulium

Identifiers

PMID29051497
PMCPMC5648820

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.