ArticleNature communications2017
Ets transcription factor GABP controls T cell homeostasis and immunity.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Epigenetic training licenses naïve CD8Science advances · 2026Article
- Genetic Architecture of Immune Cell DNA Methylation in the Rhesus Macaque.Molecular ecology · 2025Article
- Integrative ATAC-Seq and RNA-Seq Analysis Reveals Key Transcription Factors Mediating Low Salinity Adaptation in Penaeid Shrimp.International journal of molecular sciences · 2025Article
- GABP Promotes Mesangial Cell Proliferation and Renal Fibrosis Through GLI1 in Diabetic Nephropathy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Histone lactylation drives CD8Nature immunology · 2024Article
- Generation of a SARS-CoV-2-susceptible mouse model using adenovirus vector expressing human angiotensin-converting enzyme 2 driven by an elongation factor 1α promoter with leftward orientation.Frontiers in immunology · 2024Article
- Functional and transcriptional heterogeneity within the massively expanding HLADRJournal of virology · 2023Article
- NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral immunity.The EMBO journal · 2023Article
- Tox4 regulates transcriptional elongation and reinitiation during murine T cell development.Communications biology · 2023Article
- NetBID2 provides comprehensive hidden driver analysis.Nature communications · 2023Article
- Cluster-independent marker feature identification from single-cell omics data using SEMITONES.Nucleic acids research · 2022Article
- Hierarchical regulation of the resting and activated T cell epigenome by major transcription factor families.Nature immunology · 2022Article
- Whole-genome analysis of TET dioxygenase function in regulatory T cells.EMBO reports · 2021Article
- Resident memory T cells in tumor-distant tissues fortify against metastasis formation.Cell reports · 2021Article
- GABPA is a master regulator of luminal identity and restrains aggressive diseases in bladder cancer.Cell death and differentiation · 2020Article
- Specific subfamilies of transposable elements contribute to different domains of T lymphocyte enhancers.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Survival of Naïve T Cells Requires the Expression of Let-7 miRNAs.Frontiers in immunology · 2019Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Peripheral T cells are maintained in the absence of vigorous stimuli, and respond to antigenic stimulation by initiating cell cycle progression and functional differentiation. Here we show that depletion of the Ets family transcription factor GA-binding protein (GABP) in T cells impairs T-cell homeostasis. In addition, GABP is critically required for antigen-stimulated T-cell responses in vitro and in vivo. Transcriptome and genome-wide GABP-binding site analyses identify GABP direct targets encoding proteins involved in cellular redox balance and DNA replication, including the Mcm replicative helicases. These findings show that GABP has a nonredundant role in the control of T-cell homeostasis and immunity.
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Registered trials
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