ArticleNature communications2017
Genetic accommodation via modified endocrine signalling explains phenotypic divergence among spadefoot toad species.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 84 citations in OpenAlex.
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- Early onset of urea synthesis and ammonia detoxification pathways in three terrestrially developing frogs.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2023Article
- One genome, multiple phenotypes: decoding the evolution and mechanisms of environmentally induced developmental plasticity in insects.Biochemical Society transactions · 2023Review
- Does the Glucocorticoid Stress Response Make Toads More Toxic? An Experimental Study on the Regulation of Bufadienolide Toxin Synthesis.Integrative organismal biology (Oxford, England) · 2023Article
- Exploring water-borne corticosterone collection as a non-invasive tool in amphibian conservation physiology: benefits, limitations and future perspectives.Conservation physiology · 2023Article
- Chromosome-level assembly, annotation and phylome of Pelobates cultripes, the western spadefoot toad.DNA research : an international journal for rapid publication of reports on genes and genomes · 2022Article
- Context dependent variation in corticosterone and phenotypic divergence of Rana arvalis populations along an acidification gradient.BMC ecology and evolution · 2022Article
- Reproductive colonization of land by frogs: Embryos and larvae excrete urea to avoid ammonia toxicity.Ecology and evolution · 2022Article
- Article
- Thyroid hormones regulate the formation and environmental plasticity of white bars in clownfishes.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Adaptive and nonadaptive plasticity in changing environments: Implications for sexual species with different life history strategies.Ecology and evolution · 2021Article
- Stress hormones mediate developmental plasticity in vertebrates with complex life cycles.Neurobiology of stress · 2021Article
- Shifts in the developmental rate of spadefoot toad larvae cause decreased complexity of post-metamorphic pigmentation patterns.Scientific reports · 2020Article
- Identification of candidate loci for adaptive phenotypic plasticity in natural populations of spadefoot toads.Ecology and evolution · 2020Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phenotypic differences among species may evolve through genetic accommodation, but mechanisms accounting for this process are poorly understood. Here we compare hormonal variation underlying differences in the timing of metamorphosis among three spadefoot toads with different larval periods and responsiveness to pond drying. We find that, in response to pond drying, Pelobates cultripes and Spea multiplicata accelerate metamorphosis, increase standard metabolic rate (SMR), and elevate whole-body content of thyroid hormone (the primary morphogen controlling metamorphosis) and corticosterone (a stress hormone acting synergistically with thyroid hormone to accelerate metamorphosis). In contrast, Scaphiopus couchii has the shortest larval period, highest whole-body thyroid hormone and corticosterone content, and highest SMR, and these trait values are least affected by pond drying among the three species. Our findings support that the atypically rapid and canalized development of S. couchii evolved by genetic accommodation of endocrine pathways controlling metamorphosis, showing how phenotypic plasticity within species may evolve into trait variation among species.
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