ArticleJournal of applied physiology (Bethesda, Md. : 1985)2018
Parenchymal strain heterogeneity during oscillatory ventilation: why two frequencies are better than one.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 17 citations in OpenAlex.
- Simulation of Central Airway Gas Flow Dynamics During Conventional and Multifrequency Ventilation.Journal of biomechanical engineering · 2025Article
- Design and Implementation of a Computer-Controlled Hybrid Oscillatory Ventilator.Journal of medical devices · 2025Article
- Gas transport mechanisms during high-frequency ventilation.Respiratory research · 2024Review
- Diseased and healthy murine local lung strains evaluated using digital image correlation.Scientific reports · 2023Article
- Assessment of Heterogeneity in Lung Structure and Function During Mechanical Ventilation: A Review of Methodologies.Journal of engineering and science in medical diagnostics and therapy · 2022Review
- Expiratory high-frequency percussive ventilation: a novel concept for improving gas exchange.Respiratory research · 2022Article
- Associating local strains to global pressure-volume mouse lung mechanics using digital image correlation.Physiological reports · 2022Article
- Regional Gas Transport During Conventional and Oscillatory Ventilation Assessed by Xenon-Enhanced Computed Tomography.Annals of biomedical engineering · 2021Article
- Oscillatory ventilation redux: alternative perspectives on ventilator-induced lung injury in the acute respiratory distress syndrome.Current opinion in physiology · 2021Review
- The impact of steady streaming and conditional turbulence on gas transport during high-frequency ventilation.Theoretical and computational fluid dynamics · 2021Article
- High-Frequency Oscillatory Ventilation and Ventilator-Induced Lung Injury: Size Does Matter.Critical care medicine · 2020Article
- Mechanical Ventilation Lessons Learned From Alveolar Micromechanics.Frontiers in physiology · 2020Review
- Quantifying Regional Lung Deformation Using Four-Dimensional Computed Tomography: A Comparison of Conventional and Oscillatory Ventilation.Frontiers in physiology · 2020Article
- Ventilation-induced jet suggests biotrauma in reconstructed airways of the intubated neonate.Journal of the Royal Society, Interface · 2020Article
- Strain, strain rate, and mechanical power: An optimization comparison for oscillatory ventilation.International journal for numerical methods in biomedical engineering · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
High-frequency oscillatory ventilation (HFOV) relies on low tidal volumes cycled at supraphysiological rates, producing fundamentally different mechanisms for gas transport and exchange compared with conventional mechanical ventilation. Despite the appeal of using low tidal volumes to mitigate the risks of ventilator-induced lung injury, HFOV has not improved mortality for most clinical indications. This may be due to nonuniform and frequency-dependent distribution of flow throughout the lung. The goal of this study was to compare parenchymal strain heterogeneity during eucapnic HFOV when using oscillatory waveforms that consisted of either a single discrete frequency or two simultaneous frequencies. We utilized a three-dimensional, anatomically structured canine lung model for simulating frequency-dependent ventilation distribution. Gas transport was simulated via direct alveolar ventilation, advective mixing at bifurcations, turbulent and oscillatory dispersion, and molecular diffusion. Volume amplitudes at each oscillatory frequency were iteratively optimized to attain eucapnia. Ventilation using single-frequency HFOV demonstrated increasing heterogeneity of acinar flow and CO
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.