Evidence map›Paper›PMID 29051303›Full record

ArticlePhysiological reports2017

Transport-associated pathway responses in ovine fetal membranes to changes in amniotic fluid dynamics.

Cecilia Y Cheung, Debra F Anderson, Robert A Brace

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Regulation of amniotic fluid volume: insights derived from amniotic fluid volume function curves.American journal of physiology. Regulatory, integrative and comparative physiology · 2018
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Cecilia Y CheungDepartment of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon cheungce@ohsu.edu.
Debra F AndersonCenter for Developmental Health, Oregon Health and Science University, Portland, Oregon.
Robert A BraceDepartment of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon.
Oregon Health & Science University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current evidence suggests that amniotic fluid volume (AFV) is actively regulated by vesicular transport of amniotic fluid outward across the amnion and into the underlying fetal vasculature in the placenta. Our objective was to determine whether gene expression profiles of potential stimulators, inhibitors, and mediators of vesicular transport are altered in response to changes in intramembranous absorption (IMA) rate. Samples of ovine amnion and chorion were obtained from fetal sheep with normal, experimentally reduced or increased AFVs and IMA rates. Amnion and chorion levels of target mRNAs were determined by RT-qPCR In the amnion, caveolin-1 and flotillin-1 mRNA levels were unchanged during alterations in IMA rate. However, levels of both were significantly higher in amnion than in chorion. Tubulin-

Indexed as

Absorption, PhysiologicalAmniotic FluidAnimalsCaveolin 1Extraembryonic MembranesFemaleHypoxia-Inducible Factor 1, alpha SubunitMembrane ProteinsPregnancyProtein TransportRNA, MessengerSheepTubulinVascular Endothelial Growth Factor ACaveolin 1flotillinsHypoxia-Inducible Factor 1, alpha SubunitMembrane ProteinsRNA, MessengerTubulinVascular Endothelial Growth Factor AAmniotic fluid volumetubulinvascular endothelial growth factorvesicular transport

Identifiers

PMID29051303
PMCPMC5661228
OpenAlexW2765752624

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.